DU Bao-sheng~1, YAN Tian-hua~1, MA Ying~1, et al. Effects of Salidroside on Hematological System in Rats and Mice[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(2): 51-54.
DU Bao-sheng~1, YAN Tian-hua~1, MA Ying~1, et al. Effects of Salidroside on Hematological System in Rats and Mice[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(2): 51-54. DOI: 10.13422/j.cnki.syfjx.2009.02.018.
Effects of Salidroside on Hematological System in Rats and Mice
Objective:To investigate the effects of salidroside on hemorheology of rats
platelet aggregation rate in vitro in rats
coagulation time(CT) and platelet count(PC) in mice.Methods: The model of acute blood stasis was established with high-molecular weight dextran
the parameters were tested
such as blood viscosity
fibrinogen and hematocrit(Hct) etc;the effects of salidroside on platelet aggregation rate of rats
CT and PC of mice were rest after pretreatment with salidroside for 5 days.Results: Salidroside(6
12
24 mg·kg
-1
) could effectively prevent the ascending of whole blood viscosity
plasma viscosity
fibrinogen and Hct in the acute blood stasis model.Salidroside at all doses could effectively decrease platelet aggregation rate;Salidroside(48.0
24.0 mg·kg
-1
) could prolong CT and has no effect on PC.Conclusion: The results suggest that salidroside improves the hemorheological parameters of rats with acute blood stasis
and salidroside has some effects on anticoagulation
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Related Author
DU Bao-sheng1
YAN Tian-hua1
MA Ying1
WANG Qiu-juan1
YANG Wei2
WANG Guojun
ZHANG Shimin
JIN Jiao
Related Institution
Wangjing Hospital of China Academy of Chinese Medical Sciences
Guang'anmen Hospital, China Academy of Chinese Medical Sciences
Innovation Center of Classic TCM Formula
Shandong University of Traditional Chinese Medicine(TCM)
Gansu Provincial Academic Institute for Medical Research, Gansu Provincial Cancer Hospital