Effects of Sesamin on Lipidemia and Non-alcoholic Steatohepatitis in Hyperlipidemia Rats

GUO Li-qun; YANG Jie-ren~; KONG Xiang

doi:10.13422/j.cnki.syfjx.2009.02.019

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Effects of Sesamin on Lipidemia and Non-alcoholic Steatohepatitis in Hyperlipidemia Rats

更新时间：2024-09-23

- Effects of Sesamin on Lipidemia and Non-alcoholic Steatohepatitis in Hyperlipidemia Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 15, Issue 2, Pages: 55-58(2009)
- 作者机构：
  
  皖南医学院药理教研室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2009.02.019
  CLC： R285.5
- Published：2009
- 稿件说明：
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[1]郭莉群,杨解人,孔祥.芝麻素对高脂血症大鼠血脂及脂肪肝形成的影响[J].中国实验方剂学杂志,2009,15(02):55-58.

GUO Li-qun, YANG Jie-ren~, KONG Xiang. Effects of Sesamin on Lipidemia and Non-alcoholic Steatohepatitis in Hyperlipidemia Rats[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(2): 55-58.
[1]郭莉群,杨解人,孔祥.芝麻素对高脂血症大鼠血脂及脂肪肝形成的影响[J].中国实验方剂学杂志,2009,15(02):55-58. DOI： 10.13422/j.cnki.syfjx.2009.02.019.

GUO Li-qun, YANG Jie-ren~, KONG Xiang. Effects of Sesamin on Lipidemia and Non-alcoholic Steatohepatitis in Hyperlipidemia Rats[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(2): 55-58. DOI： 10.13422/j.cnki.syfjx.2009.02.019.

摘要

目的:观察芝麻素对高脂血症大鼠血脂及脂肪肝形成的影响。方法:建立高血脂大鼠模型。予不同剂量芝麻素灌胃治疗8周后

检测大鼠血脂、脂蛋白代谢酶、脂质过氧化物、载脂蛋白及肝指数、肝脏病理变化。结果:芝麻素能显著降低模型组大鼠血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白B100（ApoB100）、丙二醛（MDA）含量和肝指数

升高高密度脂蛋白胆固醇（HDL-C）、超氧化物歧化酶（SOD）、肝酯酶（HL）活性（P<0.05）;并使脂肪肝损伤得到明显改善。结论:芝麻素具有调脂和防治脂肪肝的作用

可能与调节脂质代谢及抗氧化作用等有关。

Abstract

Objective: To investigate the effects of sesamin on lipidemia and the formation of non-alcoholic steatohepatitis（NASH）.Methods: Hyperlipidemia rats model were established by feeding high lipid diet.The liver index

total cholesterol（TC）

triglyeeride（TG）

high density lipoprotein-cholesterol（HDL-C）

low density lipoprotein-cholesterol（LDL-C）

lipoprotein lipase（LPL）

hepatic lipase（HL）

apoproteinA1（ApoA1）

apoproteinB100（ApoB100）

superoxidedismutase（SOD）and malonaldehyde（MDA） were measured after administration with sesamin for 8 weeks.As well as

livers were taken for histopathological examination.Results: Therapeutic groups were significantly decreased TC

LDL-C

ApoB100

MDA and liver index

increased HDL-C

SOD（P<0.05）.The fatty degeneration and steatosis in liver were ameliorated by sesamin.Conclusion: Sesamin can remarkably modulate lipidemia and cure the NASH.Its mechanism is probably mediated through regulating lipids metabolism and anti-oxidation.

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Related Institution

The National Pharmaceutical Engineering Center

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Hospital of Chengdu University of Traditional Chinese Medicine （TCM）

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