SU Shu-lan~. Analysis the Correlation between Bioactivity on Isolated Mice Uterine Contraction and Volatile Components of Danggui-Chuanxiong[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(2): 64-67.
SU Shu-lan~. Analysis the Correlation between Bioactivity on Isolated Mice Uterine Contraction and Volatile Components of Danggui-Chuanxiong[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(2): 64-67. DOI: 10.13422/j.cnki.syfjx.2009.02.022.
Analysis the Correlation between Bioactivity on Isolated Mice Uterine Contraction and Volatile Components of Danggui-Chuanxiong
Objective: To analysis the correlation between bioactivity of inhibiting oxytocin-induced uterine contraction in vitro and volatile components of Danggui-Chuanxiong different ratio.Methods: The essential oil was extracted from Danggui-Chuanxiong by steam distillation and analyzed by GC-MS with the method of programmed temperature.Oxytocin induced female mice isolated uterine contraction model was adopted in the experiment to evaluate biological activity of Myrrh oil.Results: The experiments showed that the activities of volatile oils obtained from different ratio Danggui-Chuanxiong were different: Danggui-Chuanxiong(2∶1) > Danggui-Chuanxiong(3∶1) > Danggui-Chuanxiong(1∶1)>Danggui-Chuanxiong (3∶2);The results of GC-MS showed that the constituents of volatile oil obtained from Danggui-Chuanxiong(2∶1) were composed with the ratios of(Z)-ligustilide:(Z)-3-butylidene phthalide: 4
9-dehydro-Cycloisolongifolene: Neocnidilide:(E)-3-butylidene phthalide(80.75∶4.02∶2.07∶1.66∶0.81∶0.61∶0.53∶0.52).Conclusion: The different activities of volatile oils derived from different ratio of Danggui-Chuanxiong were resulted from the different composition of components in volatile oils.And the results suggested that the lactone-type components are possible bioactive compounds.
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Related Author
SU Shu-lan1
HUA Yong-qing1
DUAN Jin-ao1
Wang Yan-cai1
2
BAO Xing-jie1
TANG Yu-ping1
TIAN Jing
Related Institution
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences
Henan Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yuyao,Henan Research Center for Special Processing Technology of Chinese Medicine,Henan University of Chinese Medicine
Jiangxi Cancer Hospital
Jiangxi Jingde Chinese Traditional Medicine Co. Ltd.
School of Pharmacy, Jiangxi University of Chinese Medicine