The Pathological Study on Effective Compounds of TongMai in Treating MsPGN in Rats

LIU Ming-ping1; HUANG Zhao-sheng2; YANG Ni-zhi3; WEI Ping-qing1; WU Qing-guang1

doi:10.13422/j.cnki.syfjx.2009.07.027

您当前的位置：

首页 >

文章列表页 >

The Pathological Study on Effective Compounds of TongMai in Treating MsPGN in Rats

更新时间：2024-09-23

- The Pathological Study on Effective Compounds of TongMai in Treating MsPGN in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 15, Issue 7, Pages: 54-57(2009)
- 作者机构：
  
  1. 广州中医药大学中药学院
  2. 广州中医药大学护理学院
  3. 广州中医药大学第二附属医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2009.07.027
  CLC： R285.5
- Published：2009
- 稿件说明：
移动端阅览
[1]刘明平,黄兆胜,杨霓芝,韦品清,吴庆光.通脉新复方对系膜增殖性肾炎病理学改变的影响[J].中国实验方剂学杂志,2009,15(07):54-57.

LIU Ming-ping1, HUANG Zhao-sheng2, YANG Ni-zhi3, et al. The Pathological Study on Effective Compounds of TongMai in Treating MsPGN in Rats[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(7): 54-57.
[1]刘明平,黄兆胜,杨霓芝,韦品清,吴庆光.通脉新复方对系膜增殖性肾炎病理学改变的影响[J].中国实验方剂学杂志,2009,15(07):54-57. DOI： 10.13422/j.cnki.syfjx.2009.07.027.

LIU Ming-ping1, HUANG Zhao-sheng2, YANG Ni-zhi3, et al. The Pathological Study on Effective Compounds of TongMai in Treating MsPGN in Rats[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(7): 54-57. DOI： 10.13422/j.cnki.syfjx.2009.07.027.

摘要

目的:观测通脉新复方对系膜增生性肾炎（MsPGN）病理学改变的影响。方法:采用抗胸腺抗血清（ATS）制备大鼠MsPGN肾炎模型及行疲劳游泳致气虚血瘀证模型

分别ig给药高、中、低剂量（1.2

0.6

0.3 g.kg-1）通脉新复方4周。4周后进行肾组织病理学检查、免疫荧光检测IgG以及免疫组化法测定肾小球内细胞核增殖抗原PCNA的表达。结果:通脉新复方能抑制肾小球系膜增生

降低系膜区基质占毛细血管丛面积的百分比

减少大鼠肾脏系膜区IgG沉积

显著降低肾小球内PCNA阳性细胞数。结论:通脉新复方能改善系膜增生性肾炎大鼠模型肾组织病理损伤。

Abstract

Objective:To observe the therapeutic effects of effective compounds which were extracted from TongMai.Methods: SD rats experimential model with MsPGN were induced by subcutaneously injection rabbit anti-rat thymocyte serum（ATS） and forced swim.The rats were respectively ig with different dose（1.2

0.6

0.3 g·kg-1） of effective compound of TongMai for 4 weeks.Then the proliferative degree of mesangium was examined by HE stain

PAS stain and immunfluorescent respectively.Mesagium area proportion in glomerular capillaries area was calculated using image analyzing system.The expression of PCNA in the glomeruli was examined by immunohis to chemistry.Results: The effective compounds of TongMai can control the hyperplasia of the glomerular mesangial cells（GMC）and the mainifold of the mesangial matrix

and prevent the deposit of IgG in mesangium.The proportions in glomerular capillaries area in model control group were significantly higher than that in the treatment groups;The express of proliferative cell nuclear antigen（PCNA） were ascended either.Conclusion: The effective compound of TongMai can improve the damage s of pathology in glomerular.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

No data

Related Author

LIU Ming-ping1

HUANG Zhao-sheng2

YANG Ni-zhi3

WEI Ping-qing1

WU Qing-guang1

Related Institution

No data

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰