Establishment of a SD Rat Model with Vasomotor Abnormalities Induced by Dopamine and Nitroglycerin

ZHANG Zheng-xiang1; CAO Ke-gang1; GAO Yong-hong2; FAN Ji-ping3

doi:10.13422/j.cnki.syfjx.2009.07.038

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Establishment of a SD Rat Model with Vasomotor Abnormalities Induced by Dopamine and Nitroglycerin

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- Establishment of a SD Rat Model with Vasomotor Abnormalities Induced by Dopamine and Nitroglycerin
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 15, Issue 7, Pages: 65-68(2009)
- 作者机构：
  
  1. 北京中医药大学东直门医院神经内科
  2. 北京中医药大学中医内科学教育部重点实验室国家中医药管理局脑病重点研究室
  3. 中国中医科学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2009.07.038
  CLC： R-332
- Published：2009
- 稿件说明：
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[1]章正祥,曹克刚,高永红,范吉平.多巴胺、硝酸甘油诱导血管舒缩异常SD大鼠模型的建立[J].中国实验方剂学杂志,2009,15(07):65-68+71.

ZHANG Zheng-xiang1, CAO Ke-gang1, GAO Yong-hong2, et al. Establishment of a SD Rat Model with Vasomotor Abnormalities Induced by Dopamine and Nitroglycerin[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(7): 65-68.
[1]章正祥,曹克刚,高永红,范吉平.多巴胺、硝酸甘油诱导血管舒缩异常SD大鼠模型的建立[J].中国实验方剂学杂志,2009,15(07):65-68+71. DOI： 10.13422/j.cnki.syfjx.2009.07.038.

ZHANG Zheng-xiang1, CAO Ke-gang1, GAO Yong-hong2, et al. Establishment of a SD Rat Model with Vasomotor Abnormalities Induced by Dopamine and Nitroglycerin[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(7): 65-68. DOI： 10.13422/j.cnki.syfjx.2009.07.038.

摘要

目的:筛选合适的多巴胺（DA）提前给药时间

建立先后应用DA和硝酸甘油（GTN）诱导的血管舒缩异常大鼠模型。方法:大鼠分为5组:正常组、DA组、根据DA不同时间点（10

45 min）加GTN等3组

通过脉冲多普勒血流计对大鼠颈总动脉血流速度动态检测

评价DA、GTN对血流速度变化率的影响。结果:给药组的DA在注射后的10 min内血流速度变化率与正常组同时间点组间比较有差异（P<0.05）

但是从11 min起与正常组组间比较差异不显著（P>0.05）。10 min间隔组血流速度变化率与DA组在45

70 min等6个时间点比较差异有统计学意义（P<0.05或P<0.01）。45 min间隔组颈总动脉血流速度变化率与DA组在80

100 min等5个时间点比较差异有统计学意义（P<0.05）。30 min间隔组颈总动脉血流速度变化率在各个时间点与DA组比较差异没有统计学意义（P>0.05）。结论:皮下注射DA、间隔45 min再注射GTN可建立具有时相性特点的血管舒缩异常大鼠模型。该模型有可能用于防治偏头痛药物的血管活性筛选。

Abstract

Objective:To determine the appropriate time of early administration of dopamine（DA） before nitroglycerin（GTN） for establishing rat model with vasomotor abnormalities.Methods: Rats were divided into 5 groups: normal group

DA Group and other 3 groups in accordance with DA at different time points（10

45 min） plus GTN.Common carotid artery（CCA） blood flow velocity was dynamically measured with pulsed Doppler flow probe to evaluate the influence of DA

GTN on blood flow velocity rate（BFVR）.Results:The blood flow velocity rate induced by DA of All medication administration was different from the normal group within 10 minutes（P<0.05）.However

the differences were not statistically significant after 11 min（P>0.05）.The BFVR of 10min interval group had differences with the DA group at 45min

50min

55min

60min

65min and 70min（P<0.05 or P<0.01）.CCA BFVR of 45 min interval group was statistically significant different from the DA group at 80

95 min and 100 min（P<0.05）.No statistically significant differences existed between CCA BFVR of 30min interval group and DA group（P>0.05）.Conclusion: Subcutaneous injection of DA

45min after injection of GTN can induce vasomotor abnormalities in rat with phase characters.The model may be useful for vasoactive screening of anti-migraine drugs.

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Related Author

ZHANG Zheng-xiang1

CAO Ke-gang1

GAO Yong-hong2

FAN Ji-ping3

CHEN Yuhang

ZHANG Ye

CHEN Hong

ZHANG Ziwei

Related Institution

Dongfang Hospital， Beijing University of Chinese Medicine

Yunnan Provincial Hospital of Traditional Chinese Medicine

School of Clinical Medicine，Beijing University of Chinese Medicine

Beijing Key Laboratory of Chinese Materia Pharmacology，National Clinical Research Center of Traditional Chinese Medicine for Cardiovascular Diseases，Institute of Basic Medical Sciences， Xiyuan Hospital，China Academy of Chinese Medical Sciences

Natural History Museum of China

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