Effect of Panax Notoginoside on Inflammatory Reation of Rats with Acute Intracerebral Hemorrhage

XU Zhi-fang~1; TANG Lu~1; CHEN Zhi-gang~

doi:10.13422/j.cnki.syfjx.2009.09.024

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Effect of Panax Notoginoside on Inflammatory Reation of Rats with Acute Intracerebral Hemorrhage

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- Effect of Panax Notoginoside on Inflammatory Reation of Rats with Acute Intracerebral Hemorrhage
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 15, Issue 9, Pages: 77-80(2009)
- 作者机构：
  
  1. 北京中医药大学东方医院神经内科
  2. 北京中医药大学东直门医院中医脑病研究室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2009.09.024
  CLC： R285.5
- Published：2009
- 稿件说明：
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[1]徐枝芳,唐璐,陈志刚,朱陵群,扎娃,高芳,钟伟森,陈路.早期使用三七总皂苷对大鼠脑出血炎症的影响[J].中国实验方剂学杂志,2009,15(09):77-80.

XU Zhi-fang~1, TANG Lu~1, CHEN Zhi-gang~. Effect of Panax Notoginoside on Inflammatory Reation of Rats with Acute Intracerebral Hemorrhage[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(9): 77-80.
[1]徐枝芳,唐璐,陈志刚,朱陵群,扎娃,高芳,钟伟森,陈路.早期使用三七总皂苷对大鼠脑出血炎症的影响[J].中国实验方剂学杂志,2009,15(09):77-80. DOI： 10.13422/j.cnki.syfjx.2009.09.024.

XU Zhi-fang~1, TANG Lu~1, CHEN Zhi-gang~. Effect of Panax Notoginoside on Inflammatory Reation of Rats with Acute Intracerebral Hemorrhage[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(9): 77-80. DOI： 10.13422/j.cnki.syfjx.2009.09.024.

摘要

目的:早期使用三七总皂苷对大鼠脑出血（ICH）神经功能缺损和炎症介质IL-6（白细胞介素-6）、MMP-9（基质金属蛋白酶-9）的影响。方法:将SD大鼠随机分为假手术组、模型组和三七总皂苷组

采用胶原酶注射尾状核法制作脑出血模型

观察Zea Longa评分和脑出血死亡率;免疫组织化学染色法观察血肿周围IL-6和MMP-9的表达。结果:三七总皂苷组造模5 d时Zea Longa评分优于模型组（P<0.05）

造模24 h和5 d的减分值亦优于模型组（P<0.01）

且未增加脑出血死亡率;模型组48h和7 d时脑组织IL-6和MMP-9明显升高

三七总皂苷用药7 d可下调IL-6（P<0.05）和MMP-9（P<0.05）。结论:三七总皂苷可减轻大鼠脑出血后神经功能缺损

抑制IL-6和MMP-9的释放以改善神经元损伤可能是其作用机制之一。

Abstract

Objective:to discuss the effect of Panax notoginoside（PNS） on the neurologic impairment and（） 2008-06-18（ 陈志刚

）Tel:（010）67689776;E-mail:zgchen01@sina.com inflammatory factors IL-6

MMP-9 of rats with acute intracerebral hemorrhage.Method:The SD rats were divided into 3 groups randomly: sham group

model group and Panax notoginoside group.An animal model of ICH was edtablished by injecting collagenase Ⅶ into the caudate nucleus

and then Zea longa score

ICH mortality and the contents of IL-6 and MMP-9 in rat brain were measured.Results:Longa score of PNS group are lower than that of model group at the 5

day after ICH model establishment（P

0.05）.The improvement of neurologic impairment of PNS group at the 5

day compared with the 1

day are greater than that of model group（P

0.01）.The ICH mortality rate between PNS group and the model group had no significant difference.The contents of IL-6 and MMP-9 in brain tissues around hematoma of model group were significantly elevated at the 48

hour（P

0.01 and P

0.05）

and continued to rise till the 7

day（P

0.05 and P

0.01）.The inhibitive effect of PNS on the expressions of IL-6（P

0.05）

MMP-9（P

0.05）in brain on the 7

day was obvious.Conclusion:Panax notoginoside can promote recovery of neurologic impairment after ICH. One of the mechanisms may be that PNS could effectively inhibit IL-6 and MMP9.

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Related Author

XU Zhi-fang1

TANG Lu1

CHEN Zhi-gang1

ZHU Ling-qun2

ZHA Wa1

GAO Fang1

ZHONG Wei-sen1

CHEN Lu1

Related Institution

Henan University of Traditional Chinses Medicine

Division of traditional Chinese Medicine,No.252 Hospitl of PLA

College of Basic Medical Science,Hebei University

Department of Traditional Chinese Medicine

重庆市永川区中医院

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