The Application of the Micronization Technology in Zhizhu-Pills and the Produced Impact of its Dissolution

YUAN Qing-zhao~1; ZHANG Shui-han~2; YANG Ying~2; WU Lu~2; CAI Guang-xian~

doi:10.13422/j.cnki.syfjx.2009.09.035

您当前的位置：

首页 >

文章列表页 >

The Application of the Micronization Technology in Zhizhu-Pills and the Produced Impact of its Dissolution

更新时间：2024-09-23

- The Application of the Micronization Technology in Zhizhu-Pills and the Produced Impact of its Dissolution
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 15, Issue 9, Pages: 10-13(2009)
- 作者机构：
  
  1. 湖南中医药大学
  2. 湖南省中医药研究院中药超微工程技术研究中心
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2009.09.035
  CLC： R286.0
- Published：2009
- 稿件说明：
移动端阅览
[1]袁清照,张水寒,杨瑛,吴璐,蔡光先.超微粉碎技术在枳术丸中的应用及其溶出影响研究[J].中国实验方剂学杂志,2009,15(09):10-13.

YUAN Qing-zhao~1, ZHANG Shui-han~2, YANG Ying~2, et al. The Application of the Micronization Technology in Zhizhu-Pills and the Produced Impact of its Dissolution[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(9): 10-13.
[1]袁清照,张水寒,杨瑛,吴璐,蔡光先.超微粉碎技术在枳术丸中的应用及其溶出影响研究[J].中国实验方剂学杂志,2009,15(09):10-13. DOI： 10.13422/j.cnki.syfjx.2009.09.035.

YUAN Qing-zhao~1, ZHANG Shui-han~2, YANG Ying~2, et al. The Application of the Micronization Technology in Zhizhu-Pills and the Produced Impact of its Dissolution[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(9): 10-13. DOI： 10.13422/j.cnki.syfjx.2009.09.035.

摘要

目的:对经微粉化制备的枳术丸与枳术丸进行显微、理化鉴别、溶出情况对比研究

探索超微粉碎对丸剂质量的影响。方法:采用TLC法鉴别枳实与白术、采用HPLC法测定枳术丸橙皮苷的体外溶出情况

并采用了Weibull分布模型进行溶出动力学模拟。结果:超微粉碎与普通粉碎后TLC无显著差别

经微粉化制备的枳术丸各时间点的有效成分溶出较普通丸剂快。结论:枳术丸经超微粉碎后橙皮苷溶出量增加

溶出速度明显提高。

Abstract

Objective:To search for the micronization impact to the pill preparation

we carry out a series of comparative study on the micro characteristic、TLC characteristic、dissolution results of Ultro-micro and Normal powder of Zhizhu pill.Method:Using Fructus Aurantii Immaturus and Rhizoma Atractylodis Macrocephalae

the TLC information can be identified.Taking Hesperidin as the index component

the dissolution character were compared.The Weibull distribution analysis system were also applied.Result:We can see the almost similar TLC characteristic in the two pills

however the significant differences can be identified in the dissolution study on the Ultro-micro and the normal pills.Obviously

the dissolution rate and the total quantity of Hesperidin in the ultro-micro pills were increaseed.Conclusion:The active component of the pills can not be destructed in the process of micronization.Moreover

this behavior truly increase the vitro-utilization of the preparation.

关键词

Keywords

references

Views

231

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Anticancer Mechanism of Hesperidin and Its Derivatives： A Review

HPLC Determination of Four Flavonoids of Aurantii Fructus Immaturus in Niuhuang Qingwei Pills and Genetic Analysis of Medicinal Materials

Analysis of Fingerprint of Standard Decoction of Citri Reticulatae Pericarpium Based on Spectroscopic Method

Related Author

YUAN Qing-zhao1

ZHANG Shui-han2

YANG Ying2

WU Lu2

CAI Guang-xian1

TIAN Xiurong

WANG Hao

Related Institution

The People's Hospital Affiliated to Chongqing Three Gorges Medical College

Institute of Basic Research in Clinical Medicine，China Academy of Chinese Medical Sciences

Chongqing Three Gorges Medical College

Shandong University of Traditional Chinese Medicine

National Institutes for Food and Drug Control

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰