Review of Experimental Studies on Nonalcoholic Fatty Liver Disease

WENG Xiao-gang; ZHU Xiao-xin; YANG Qing; LI Yu-jie

doi:10.13422/j.cnki.syfjx.2009.11.003

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Review of Experimental Studies on Nonalcoholic Fatty Liver Disease

更新时间：2024-09-23

- Review of Experimental Studies on Nonalcoholic Fatty Liver Disease
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 15, Issue 11, Pages: 104-109(2009)
- 作者机构：
  
  中国中医科学院中药研究所
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2009.11.003
  CLC： R259
- Published：2009
- 稿件说明：
移动端阅览
[1]翁小刚,朱晓新,杨庆,李玉洁.非酒精性脂肪肝的实验研究进展[J].中国实验方剂学杂志,2009,15(11):104-109.

WENG Xiao-gang, ZHU Xiao-xin, YANG Qing, et al. Review of Experimental Studies on Nonalcoholic Fatty Liver Disease[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(11): 104-109.
[1]翁小刚,朱晓新,杨庆,李玉洁.非酒精性脂肪肝的实验研究进展[J].中国实验方剂学杂志,2009,15(11):104-109. DOI： 10.13422/j.cnki.syfjx.2009.11.003.

WENG Xiao-gang, ZHU Xiao-xin, YANG Qing, et al. Review of Experimental Studies on Nonalcoholic Fatty Liver Disease[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(11): 104-109. DOI： 10.13422/j.cnki.syfjx.2009.11.003.

摘要

非酒精性脂肪肝（NAFLD）包括单纯性脂肪肝、脂肪性肝炎、脂肪性肝纤维化和肝硬化。目前尚无治疗NAFLD的特殊有效药物。本文查阅十年间国内外相关文献80余篇

对NAFLD的发病机制及新学说、NAFLD研究模型及观察指标

以及中药治疗NAFLD的研究情况进行了阐述。NAFLD的发病机制主要包括脂质代谢紊乱、胰岛素抵抗（IR）等

与IR有关的"二次打击学说"能够合理地解释NAFLD的形成机制。NAFLD研究模型主要包括整体动物实验模型和体外细胞模型

观察指标主要涉及脂质代谢、一些特殊细胞如Kupffer细胞等。中医治疗NAFLD具有一定优势。

Abstract

Nonalcoholic fatty liver disease（NAFLD） is a sort of parenchymal lesion not caused by excessive consumption of alcohol.It includes simplex fatty liver

steatohepatitis

greasy hepatic fibrosis and cirrhosis.NAFLD encompasses a spectrum of common hepatic disorders in contemporary society with multiple pathologic consequences and is incidence is paralleling the increasing numbers of overweight and obese individuals worldwide.The pathogenesis of NAFLD is thought to be related mainly with insulin resistance syndrome and oxidative stress

and no effective drug can be obtained in the market for treatment of NAFLD.Large experimental studies on NAFLD are in progress recently.This review outlines the experimental studies about NAFLD and the advantage of traditional Chinese medicine in treatment of NAFLD.

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WENG Xiao-gang

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Related Institution

College of Integrated Traditional Chinese and Western Medicine， Hunan University of Chinese Medicine

New Drug Research and Development Center of Guangdong Pharmaceutical University

Gansu Authority of Chinese Medicine

Affiliated Hospital of Gansu College of Traditional Chinese Medicine

Gansu College of Traditional Chinese Medicine

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