Effect of Drugs of Invigorating Spleen,Heat-clearing and Eliminating Stasis on QOUH in the Rat Model of Gastric Ulcer

LV Guan-hua~1; BAO Yong-xin~

doi:10.13422/j.cnki.syfjx.2009.11.024

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Effect of Drugs of Invigorating Spleen,Heat-clearing and Eliminating Stasis on QOUH in the Rat Model of Gastric Ulcer

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- Effect of Drugs of Invigorating Spleen,Heat-clearing and Eliminating Stasis on QOUH in the Rat Model of Gastric Ulcer
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 15, Issue 11, Pages: 63-66(2009)
- 作者机构：
  
  1. 辽宁中医药大学附属第二医院
  2. 解放军第四六三医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2009.11.024
  CLC： R285.5
- Published：2009
- 稿件说明：
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[1]吕冠华,包永欣,李海泉,赵金婷.健脾清热化瘀中药对胃溃疡愈合质量影响的实验研究[J].中国实验方剂学杂志,2009,15(11):63-66.

LV Guan-hua~1, BAO Yong-xin~. Effect of Drugs of Invigorating Spleen,Heat-clearing and Eliminating Stasis on QOUH in the Rat Model of Gastric Ulcer[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(11): 63-66.
[1]吕冠华,包永欣,李海泉,赵金婷.健脾清热化瘀中药对胃溃疡愈合质量影响的实验研究[J].中国实验方剂学杂志,2009,15(11):63-66. DOI： 10.13422/j.cnki.syfjx.2009.11.024.

LV Guan-hua~1, BAO Yong-xin~. Effect of Drugs of Invigorating Spleen,Heat-clearing and Eliminating Stasis on QOUH in the Rat Model of Gastric Ulcer[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(11): 63-66. DOI： 10.13422/j.cnki.syfjx.2009.11.024.

摘要

目的:探讨健脾清热化瘀中药对大鼠乙酸性胃溃疡愈合质量的影响。方法:采用冰醋酸注射法制备大鼠胃溃疡模型

随机分为模型组、雷尼替丁组（西药组）、健脾中药组、清热中药组、化瘀中药组、健脾清热化瘀中药组（合用组）和正常对照组（空白组）。于给药14 d后在光镜下观察溃疡指数（UI）、再生黏膜厚度、黏膜肌层缺损宽度及囊状扩张腺体数量

应用ELISA法检测血清表皮生长因子（EGF）及6-酮-前列腺素F1α（6-keto-PGF1α）含量

免疫组化法检测胃黏膜表皮生长因子受体（EGFR）的表达。结果:健脾、清热、化瘀中药及其合方都能使再生黏膜厚度增加

黏膜肌层缺损宽度及囊状扩张腺体数量减少

与模型组比较P<0.01

中药合方组疗效明显优于西药组（P<0.05或P<0.01）。健脾清热化瘀中药可明显提高血清6-keto-PGF1α含量

与模型组比较P<0.01

接近空白组水平

明显高于雷尼替丁组（P<0.05）。中药各组及西药组血清EGF含量较模型组及空白组升高（P<0.01）

且可明显增强胃溃疡黏膜EGFR的表达（P<0.05或P<0.01）

尤以中药合方组疗效最为明显（P<0.01）。结论:健脾清热化瘀中药通过改善胃溃疡再生黏膜组织学成熟度和功能成熟度

可明显改善实验性胃溃疡愈合质量

有效减少复发。

Abstract

Objective:To study the effect of drugs of invigorating spleen

heat-clearing

eliminating stasis on QOUH in rat model of gastric ulcer.Methods:The rat model of gastric ulcer was constructed by injection of acetic acid.The rats were randomly divided into model group

ranitidine group

invigorating spleen group

heating-clearing group

eliminating stasis group

complex prescription group and normal control group.The ulcer index（UI）

regenerated mucosal thickness

lamina muscularis mucosal width and capsular broaden glandular organ quantity were observed by HE

and the levels of EGF and 6-keto-PGF

1α

were detected by ELISA.The expression of EGFR in the mucosa around the ulcer was detected by SABC kit immunohistochemical method.Results:Compared with Model group

the regenerated mucosal thickness

lamina muscularis mucosae defect extent

UI and capsular broaden glandular organ quantity in invigoraing spleen

heat-clearing

elimianting stasis and complex prescription treating groups were different significantly（P

0.01）.And the effect of complex prescription was better than ranitidine in different degree（P

0.05

or P

0.01）.Compared with ranitidine

invigorating spleen group

heating-clearing group

eliminating stasis increased the levels of 6-keto-PGF

1α

closed to the normal.Compared with model group and normal control group

the levels of EGF in serum in treating groups were increased significantly（P

0.01）.Positive expression of EGFR around ulcerative tissues in treating groups were strengthened obviously（P

0.05

or P

0.01）

and the effect of complex prescription was the best（P

0.01）.Conclusion:Drugs of invigorating spleen

heat-clearing and eliminating stasis can improve the QOUH and prevent from recurring by improving histological maturation and functional maturation of regenerative mucosa in GU rats.

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Related Author

LV Guan-hua1

BAO Yong-xin2

LI Hai-quan1

ZHAO Jin-ting1

LI Jiaze

SHEN Xiaopu

XIANG Xi

GUO Hui

Related Institution

The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine

School of Pharmacy， Academy of Chinese Medical Sciences， Henan University of Chinese Medicine

School of Pharmacy of Anhui University of Chinese Medicine，Anhui Province Key Laboratory of Chinese Medicinal Compounds，Synergetic Innovation Center of Anhui Authentic Chinese Medicine， Heifei

Academy of Traditional Chinese Medicine，Henan University of Chinese Medicine

Li Zhenhua Institute of Academic Thought， Henan University of Chinese Medicine

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