WU Mei-ping~. Effects of "ethanol extract from Polygonatum Odoratum" on Hemodynamics in Rats of Heart Failure Following Myocardial Infarction[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(11): 67-70.
WU Mei-ping~. Effects of "ethanol extract from Polygonatum Odoratum" on Hemodynamics in Rats of Heart Failure Following Myocardial Infarction[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(11): 67-70. DOI: 10.13422/j.cnki.syfjx.2009.11.025.
Effects of "ethanol extract from Polygonatum Odoratum" on Hemodynamics in Rats of Heart Failure Following Myocardial Infarction
Objective:Objective:To observe the effects and dose-effect relationship of "ethanol extract from Polygonatum Odoratum" on Hemodynamics in Rats of Heart Failure Following Myocardial Infarction.Methods:Seventy healthy Sprague-Dawley rats were divived randomly into sham group
model group
large dosage of "ethanol extract from Polygonatum Odoratum" group
moderate dosage of "ethanol extract from Polygonatum Odoratum" group
small dosage of "ethanol extract from Polygonatum Odoratum" group.After successful model duplication
rats in different dosage of "ethanol extract from Polygonatum Odoratum" groups were treated with intravenous injection of 6 g/kg
3 g/kg
0.3 g/kg distinctly
while rats in sham group or model group received 6 ml/kg saline.The heart rate(HR)
left ventricular systolic pressure(LVSP)
left ventricular diastolic pressure(LVDP)
maximum rise speed of left ventricular pressure(+dp/dtmax)
maximum drop speed of left ventricular pressure(-dp/dtmax)were measured at different time points(before injection and 5
10
20
30 minutes after injection)and comparatively analyed.Result:The HR decreased at 5 minutes in large dosage group and model group
the LVSP was lower
the +dp/dtmax and-dp/dtmax were slower
the LVDP increased at the same time
all these parameter went back to normal at 20 and 30 minutes points
the small dosage group was found changes in these parameters at 10 minutes point except HR.Conclusion:"ethanol extract from Polygonatum Odoratum" has negative inotropic and negative chronotropic action in CHF rats.These two actions have dose-effect relationship.
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Related Author
吴美平1
3
熊旭东2
董耀荣1
3
王俊龙3
WU Mei-ping
DONG Yao-rong
Related Institution
Shanghai University of Traditional Chinese Medicine
Anhui Province Key Laboratory of Chinese Medicinal Formula
School of Integrated Chinese Medicine and Western Medicine,Anhui University of Chinese Medicine
School of Chinese Medicine,Anhui University of Chinese Medicine