Anti-tumor Activity of the Semi-synthesis Derivative of Triptolide on Mice with Transplanted Human Colonic Tumor Cells

SU Dan~1; GUO Shan-shan~1; JIN Ya-hong~1; ZHANG Yi~1; SHI Yu-jing~1; YUAN Gui-dong~1; CUI Xiao-lan~1; WANG Yi-zhong~2; ZHANG Yu-jie~3

doi:10.13422/j.cnki.syfjx.2009.11.027

您当前的位置：

首页 >

文章列表页 >

Anti-tumor Activity of the Semi-synthesis Derivative of Triptolide on Mice with Transplanted Human Colonic Tumor Cells

更新时间：2024-09-23

- Anti-tumor Activity of the Semi-synthesis Derivative of Triptolide on Mice with Transplanted Human Colonic Tumor Cells
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 15, Issue 11, Pages: 58-60(2009)
- 作者机构：
  
  1. 中国中医科学院中药研究所
  2. 北京大学航天临床医学院
  3. 北京美迪克斯生物技术有限公司
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2009.11.027
  CLC： R285.5
- Published：2009
- 稿件说明：
移动端阅览
[1]苏丹,郭姗姗,金亚宏,张毅,时宇静,原桂东,崔晓兰,王意忠,张玉杰.雷公藤内酯醇半合成衍生物对人结肠癌细胞系荷瘤小鼠肿瘤抑制作用的研究[J].中国实验方剂学杂志,2009,15(11):58-60.

SU Dan~1, GUO Shan-shan~1, JIN Ya-hong~1, et al. Anti-tumor Activity of the Semi-synthesis Derivative of Triptolide on Mice with Transplanted Human Colonic Tumor Cells[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(11): 58-60.
[1]苏丹,郭姗姗,金亚宏,张毅,时宇静,原桂东,崔晓兰,王意忠,张玉杰.雷公藤内酯醇半合成衍生物对人结肠癌细胞系荷瘤小鼠肿瘤抑制作用的研究[J].中国实验方剂学杂志,2009,15(11):58-60. DOI： 10.13422/j.cnki.syfjx.2009.11.027.

SU Dan~1, GUO Shan-shan~1, JIN Ya-hong~1, et al. Anti-tumor Activity of the Semi-synthesis Derivative of Triptolide on Mice with Transplanted Human Colonic Tumor Cells[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(11): 58-60. DOI： 10.13422/j.cnki.syfjx.2009.11.027.

摘要

目的:观察和评价雷公藤内酯醇的半合成衍生物（MC002）对人结肠癌HCT-8小鼠模型的肿瘤抑制作用。方法:用BALB/C裸小鼠接种人结肠癌HCT-8瘤株造成小鼠肿瘤模型

以MC002对荷瘤小鼠的相对肿瘤增殖率、瘤重、抑瘤率为指标评价MC002对小鼠的抑瘤作用。结果:MC002各剂量组瘤体积明显小于模型对照组

瘤重均显著降低

在1.5 mg.kg-1、1.0 mg.kg-1给药10次后T/C%均小于40%（P<0.05）

且具有量效关系。结论:MC002能有效抑制人结肠癌HCT-8荷瘤小鼠体内肿瘤生长。通过深入研究MC002有可能发展成为一种新型抗癌药。

Abstract

Objective:To observe and evaluate the anti-tumor effect of MC002

the semi synthesis derivative of triptolide

on human colonic tumor in HCT-8 mice.Methods: BALB/c nude mice of human colonic tumor model was made through HCT-8 cells inoculation.Anti-tumor activity of MC002 was evaluated in terms of relative tumor growth rate

tumor weight and tumor inhibitory ratio in mice transplanted.Results: Tumor volume and weight in every MC002 dosage group were obviously smaller than that in the control group.after ten times of administration

the values of T/C% in the groups of 1.5 mg·kg

-1

and 1.0 mg·kg

-1

were less than 40% with dose-effect relation ship.Conclusion:MC002 has significant restraining effect on the growth of HCT-8 tumor in mice.It may be developed into a new promising anticancer drug through further studies.

关键词

Keywords

references

Views

242

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

No data

Related Author

SU Dan1

GUO Shan-shan1

JIN Ya-hong1

Zhang Yi1

SHI Yu-jing1

YUAN Gui-dong1

CUI Xiao-lan1

WANG Yi-zhong2

Related Institution

No data

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰