CHEN Ying-li, LI Wei, FU Ping, et al. Effect of Parenteral Injection of Milkvetch Root Saponin on Myocardial Contraction in Heart Failure Dogs[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(11): 79-81.
CHEN Ying-li, LI Wei, FU Ping, et al. Effect of Parenteral Injection of Milkvetch Root Saponin on Myocardial Contraction in Heart Failure Dogs[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(11): 79-81. DOI: 10.13422/j.cnki.syfjx.2009.11.031.
Effect of Parenteral Injection of Milkvetch Root Saponin on Myocardial Contraction in Heart Failure Dogs
Objective:Methods:Results:Conclusions:To study the effect of parenteral injection of milkvetch root saponin on myocardial contraction in experimental heart failure dogs.Methods:Acute heart failure model in anesthetic dogs was induced by using pentobarbital sodium
the central depressant.Parenteral injection of milkvetch root saponin was injected through vein.Then the heart function parameters
e.g.left ventricular systolic pressure(LVSP)
left ventricular end-diastolic pressure(LVEDP)
contractive pressure maximum upstroke velocity(+dp/dt
max
)
diastolic pressure maximum descent velocity(-dp/dt
max
)
and heart rate(HR) were determined.Results: Milkvetch root saponin could obviously increase heart failure dogs’ LVSP
+dp/dt
max
-dp/dt
max
while it had no significant effect on LVEDP and HR.Conclusion: The injection of milkvetch root saponin can enhance myocardial contractility
improve the functions of myocardial contraction and relaxation
and it has obvious effect in treating acute heart failure.