The Protective Effect of Qingzaojiufei Soup on Radiation-induced Pulmonary Injury and Its Impact on Cell Growth Factor——CTGF,PDGF

SHEN Wei-sheng; XIA De-hong; XI Lei; ZHOU Jian-bo; HOU Xing-heng; WANG Ke; LI Shao-ping; SHU Zhong-qin

doi:10.13422/j.cnki.syfjx.2009.11.041

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The Protective Effect of Qingzaojiufei Soup on Radiation-induced Pulmonary Injury and Its Impact on Cell Growth Factor——CTGF,PDGF

更新时间：2024-09-23

- The Protective Effect of Qingzaojiufei Soup on Radiation-induced Pulmonary Injury and Its Impact on Cell Growth Factor——CTGF,PDGF
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 15, Issue 11, Pages: 95-98(2009)
- 作者机构：
  
  东南大学医学院附属江阴医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2009.11.041
  CLC： R273;R730.5
- Published：2009
- 稿件说明：
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[1]沈伟生,夏德洪,奚蕾,周剑波,候昕珩,王珂,刘少平,舒忠琴.清燥救肺汤对放射性肺损伤干预作用及对细胞生长因子——CTGF、PDGF影响的研究[J].中国实验方剂学杂志,2009,15(11):95-98.

SHEN Wei-sheng, XIA De-hong, XI Lei, et al. The Protective Effect of Qingzaojiufei Soup on Radiation-induced Pulmonary Injury and Its Impact on Cell Growth Factor——CTGF,PDGF[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(11): 95-98.
[1]沈伟生,夏德洪,奚蕾,周剑波,候昕珩,王珂,刘少平,舒忠琴.清燥救肺汤对放射性肺损伤干预作用及对细胞生长因子——CTGF、PDGF影响的研究[J].中国实验方剂学杂志,2009,15(11):95-98. DOI： 10.13422/j.cnki.syfjx.2009.11.041.

SHEN Wei-sheng, XIA De-hong, XI Lei, et al. The Protective Effect of Qingzaojiufei Soup on Radiation-induced Pulmonary Injury and Its Impact on Cell Growth Factor——CTGF,PDGF[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(11): 95-98. DOI： 10.13422/j.cnki.syfjx.2009.11.041.

摘要

目的:观察清燥救肺汤对局部中晚期胸部肿瘤放射治疗的肺保护作用及对结缔组织生长因子（CTGF）、血小板源性生长因子（PDGF）在体内水平的影响。方法:将局部中晚期胸部肿瘤放射治疗者随机分为治疗组和对照组。治疗组在放射治疗开始起服用清燥救肺汤连续6个月。放射治疗前后测定血浆CTGF和PDGF

放射治疗15天起开始观察临床症状、高分辨率CT治疗前和治疗后5个月和10个月测定肺弥散功能。结果:治疗组放射治疗后血浆CTGF和PDGF明显低于对照组（P<0.001）。放射治疗开始后5个月和10个月治疗组CO弥散量下降情况较对照组差异有统计学意义（P<0.05）。治疗组急性放射性肺炎和肺纤维化的发生率比对照组显著降低（P<0.05）。结论:清燥救肺汤能抑制放射治疗后血浆CTGF和PDGF的过度释放

降低放射治疗后弥散功能的恶化。

Abstract

Objective:To observe the pulmonary protective effect and impacts of local chest radiotherapy in corpore levels of connective tissue growth factor（CTGF）and platelet-derived growth factor（PDGF） after Qingzaojiufei soup treatment in patients with advanced and mediate chest tumor.Methods: The patients with advanced-mediate chest tumors who were ready to local radiotherapy were randomly divided into treatment group and control group.Qinzaojiufei soup was taken for 6 months in the treatment group from the beginning of radiotherapy.The levels of plasma CTGF and PDGF were detected before and after radiotherapy.Clinical symptoms

high-resolution CT and pulmonary diffusing capacity were observed from 15th days after the beginning of radiotherapy.Results: There were significantly difference in the concentration of plasma CTGF and plasma PDGF（P<0.001）in control group compared with the treatment group after radiation therapy. There was statistically significant difference in CO diffusing capacity

acute radiation pneumonia and the incidence of pulmonary fibrosis in treament group compared with control group after the 5 months and 10 months radiotherapy（P<0.05）.Conclusion: Qinzaojiufei soup can inhibit over-liberation of plasma CTGF and PDGF induced by radiotherapy to reduce the deterioration of pulmonary diffusing capacity.

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SHEN Wei-sheng

XIA De-hong

XI Lei

ZHOU Jian-bo

HOU Xing-heng

WANG Ke

LI Shao-ping

SHU Zhong-qin

Related Institution

School of Integrated Chinese and Western Medicine，Anhui University of Chinese Medicine

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Key Laboratory of Xin'an Medicine， Ministry of Education， Anhui University of Chinese Medicine

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