Pharmacokinetics of Berberine in Rat Intestinal and Bile Following Intravenous Administration of Coptidis Rhizoma Extract

WANG Ming-wei~1; WANG Xue-li~2; XING Dong-ming~2; LEI Fan~2; DU Li-jun~

doi:10.13422/j.cnki.syfjx.2010.01.029

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Pharmacokinetics of Berberine in Rat Intestinal and Bile Following Intravenous Administration of Coptidis Rhizoma Extract

更新时间：2024-09-23

- Pharmacokinetics of Berberine in Rat Intestinal and Bile Following Intravenous Administration of Coptidis Rhizoma Extract
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 1, Pages: 46-50(2010)
- 作者机构：
  
  1. 新疆军区西安第二干休所医务室
  2. 清华大学生物科学与技术系药物药理研究室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.01.029
  CLC： R285.5
- Published：2010
- 稿件说明：
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[1]王明玮,王雪莉,邢东明,雷帆,杜力军.小檗碱在大鼠小肠及胆汁中药代动力学研究[J].中国实验方剂学杂志,2010,16(01):46-50.

WANG Ming-wei~1, WANG Xue-li~2, XING Dong-ming~2, et al. Pharmacokinetics of Berberine in Rat Intestinal and Bile Following Intravenous Administration of Coptidis Rhizoma Extract[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(1): 46-50.
[1]王明玮,王雪莉,邢东明,雷帆,杜力军.小檗碱在大鼠小肠及胆汁中药代动力学研究[J].中国实验方剂学杂志,2010,16(01):46-50. DOI： 10.13422/j.cnki.syfjx.2010.01.029.

WANG Ming-wei~1, WANG Xue-li~2, XING Dong-ming~2, et al. Pharmacokinetics of Berberine in Rat Intestinal and Bile Following Intravenous Administration of Coptidis Rhizoma Extract[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(1): 46-50. DOI： 10.13422/j.cnki.syfjx.2010.01.029.

摘要

目的:研究大鼠静脉注射黄连生物碱提取物后

小檗碱在大鼠小肠和胆汁中的药代动力学特性。方法:用高效液相色谱（HPLC）检测大鼠小肠和胆汁样品中小檗碱的浓度。结果:黄连生物碱中小檗碱在静脉给药后0.25

B/P（胆汁中浓度/血浆中浓度）为69.1

97.9

属于胆汁清除率高的药物。胆汁引流实验表明

小肠中绝大部分的小檗碱来自胆汁。引流胆汁后

给大鼠静脉给药

在小肠中仍能检测到小檗碱

推测这一部分小檗碱来自于血浆中的小檗碱

其转运方向是从侧底膜（basolateral membrane）向顶侧膜（apical membrane）转运至小肠中。结论:实验从整体动物水平上证明了小檗碱在血液中可以逆向转运至小肠中

其转运机理涉及P-糖蛋白（P-glycoprotein

P-gp）。

Abstract

Objective: To investigate the pharmacokinetics of berberine in Coptidis Rhizoma extract in rat intestinal and bile.Method: A simple and accurate high-performance liquid chromatography method was used to determine the concentration of berberine in the rat intestinal and bile samples.Result: Following the intravenous administration of Coptidis Rhizoma extract

B/P（concentration in the bile/concentration in the plasma） of berberine was determined to be 69.1～497.9 from 0.25 h to 4 h.Bile excretion was one of the main excretion ways for rats to eliminate berberine of Coptidis Rhizoma alkaloids.Most of berberine in the intestinal was from the bile.While bile was discharged from rats

berberine still could be determined in the intestinal.Conclusion: The results proved that berberine could be transported from blood to intestinal in the animal model with a direction from basolateral membrane to apical membrane.P-glycoprotein is involved in the transport mechanism.

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Related Author

WANG Ming-wei

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LEI Fan

DU Li-jun

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Related Institution

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