LI Dong~1, CHEN Zhi-wu~2, CEN De-yi~2, et al. The Study of Anti-bradycardic Effect and Mechanism of Ganfu Granule in Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(1): 68-71.
LI Dong~1, CHEN Zhi-wu~2, CEN De-yi~2, et al. The Study of Anti-bradycardic Effect and Mechanism of Ganfu Granule in Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(1): 68-71. DOI: 10.13422/j.cnki.syfjx.2010.01.035.
The Study of Anti-bradycardic Effect and Mechanism of Ganfu Granule in Rats
Objective:To study the anti-bradycardic mechanism of Ganfu granule in rats.Methods: The bradycardic model in rats was induced by propranolol(Pro). the activity of glutathione peroxidase(GSH-PX)
superoxide dismutase(SOD) and the content of Malonydialdehyde(MDA) in heart tissue were detected;the content of cyclic adenosine monophosphate(cAMP)
cyclic guanosine monophosphate(cGMP) in heart tissue as well as the content of calcitonin gene-related peptide(CGRP)
endothelin(ET) in plasma were detected by radioimmunoassay.Results: Ganfu granule(30
90
270 mg·kg
-1
) significantly inhibited the Pro-induced decrease of heart rate in rats
reduced the content of MDA
cGMP in heart tissue
markedly increased the content of CGRP in plasma and the ratio of cAMP/cGMP in heart tissue. Gan granule(90
270 mg·kg
-1
) markedly increased the activity of SOD and GSH-PX in heart tissue;Compare with model group
the changes of the content of ET in plasma and cAMP in heart tissue were not obviouse.Conclusion:The anti-bradycardic mechanism of Ganfu granule may be related to anti-free radicals
The Study of Anti-bradycardic Effect and Mechanism of Ganfu Granule in Rats
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Related Author
LI Dong
CHEN Zhi-wu
CEN De-yi
WANG Di-sheng
NIE Zi-wen
GUO Jian-sheng
CHEN Jun
ZHANG Meng
Related Institution
Shijiazhuang Medical College
Baixiang Country Central Hospital
Pingxiang Hospital of Traditional Chinese Medicine
National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines, Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences
School of Pharmacy, Hunan University of Chinese Medicine