WANG Xin~. Effects of Chai Shao He Wei Granules on Chronic Superficial Gastritis in Mouse Model[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(1): 76-79.
WANG Xin~. Effects of Chai Shao He Wei Granules on Chronic Superficial Gastritis in Mouse Model[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(1): 76-79. DOI: 10.13422/j.cnki.syfjx.2010.01.038.
Effects of Chai Shao He Wei Granules on Chronic Superficial Gastritis in Mouse Model
Objective:To observe the effects of Chai Shao He Wei Granules(CSHW) on chronic superficial gastritis in mouse model induced by methimazole.Methods:Established mice model of chronic superficial gastritis by administrating methimazole for 28 days;Three weeks after drug administration histopathology of gastric mucosa was observed by HE stain.The contents of PGE
2
phosphatide and aminohexose in gastric mucosa were detected by chemical colorimetry;and the content of serum gastrin was detected by radioimmunoassay.Results: Compared with model group
CSHW high dose group could reduce the pathological damage of chronic superficial gastritis in mice
increase the content of aminohexose
elevate the levels of PGE
2
and phosphatide and reduce the level of gastrin in serum
respectively.Conclusions: CSHW could obviously reduce the inflammation and damage in gastric mucosa of chronic superficial gastritis induced by methimazole in mice and protect the gastric mucosa.The effect may be related to the increase of aminohexose in gastric mucosa
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Dongzhimen Hospital, Beijing University of Chinese Medicine
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