ZHANG Jun-li~1, JIA Cheng~2, YUAN Bo~1, et al. The Effect and Mechanism of Radix Notoginseng Compound on Inhibition of Thrombosis[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(2): 81-83.
ZHANG Jun-li~1, JIA Cheng~2, YUAN Bo~1, et al. The Effect and Mechanism of Radix Notoginseng Compound on Inhibition of Thrombosis[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(2): 81-83. DOI: 10.13422/j.cnki.syfjx.2010.02.039.
The Effect and Mechanism of Radix Notoginseng Compound on Inhibition of Thrombosis
Objective:To study the effect and mechanism of Radix Notoginseng compound on inhibition of thrombosis.Methods: The rat thrombosis nodel was induced by electric stimulation.The influences of Radix Notoginseng Compound on thrombus formation and hemorheological parameters were investigated.The rat model of blood stasis was established by combined application of epinephrine with ice bath.The influences of the compound on thrombixin A
2
and prostaglandin I
2
were observed for the model.Results: Compared with the control group
each dose of Radix Notoginseng Compound and aspirin tablet could extend the latency period for thrombus formation
and decrease blood viscosity.The compound could significantly increase the plasma levels of 6-Keto-PGF
1α
and the ratio of 6-Keto-PGF
1α
/TXB
2
for the blood stasis rats(both P
<
0.01).The level of TXB
2
was significantly decreased(P
<
0.05).Conclusion:Radix Notoginseng compound has inhibitive effect on thrombosis
the mechanism of action is closely related with decrease in blood viscosity and chang in the PGI
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Related Author
ZHANG Jun-li
JIA Cheng
YUAN Bo
WANG Yang
CHENG Jia-yi
CHU Jianfeng
HE Chenchen
WEI Chenyi
Related Institution
College of Integrative Medicine and Academy of Integrative Medicine,Fujian University of Traditional Chinese Medicine(TCM)
Fujian Key Laboratory of Integrative Medicine on Geriatrics
Chen Keji Academic Thought Inheritance Studio,Fujian University of TCM
Xiyuan Hospital, China Academy of Chinese Medical Sciences
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences