Study on quality control of Alpinia officiarum formula granules

TU Yao-sheng1; LI Zhi-yong1

doi:10.13422/j.cnki.syfjx.2010.04.016

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Study on quality control of Alpinia officiarum formula granules

更新时间：2024-09-23

- Study on quality control of Alpinia officiarum formula granules
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 4, Pages: 21-23(2010)
- 作者机构：
  
  1. 广东省中医研究所
  2. 广州中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.04.016
  CLC： R286
- Published：2010
- 稿件说明：
移动端阅览
[1]涂瑶生,李智勇.高良姜配方颗粒质量控制研究[J].中国实验方剂学杂志,2010,16(04):21-23.

TU Yao-sheng1, LI Zhi-yong1. Study on quality control of Alpinia officiarum formula granules[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(4): 21-23.
[1]涂瑶生,李智勇.高良姜配方颗粒质量控制研究[J].中国实验方剂学杂志,2010,16(04):21-23. DOI： 10.13422/j.cnki.syfjx.2010.04.016.

TU Yao-sheng1, LI Zhi-yong1. Study on quality control of Alpinia officiarum formula granules[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(4): 21-23. DOI： 10.13422/j.cnki.syfjx.2010.04.016.

摘要

目的:探讨高良姜配方颗粒质量控制方法并为其质量控制提供参考。方法:采用薄层色谱法对不同批次高良姜配方颗粒进行定性鉴别;采用HPLC法测定其中高良姜素和山奈素的含量。phenomenex Gemini C18（4.6 mm×250 mm

5μm）色谱柱;流动相甲醇-0.4%磷酸（58∶42）;检测波长360 nm;流速1.0 mL.min-1;柱温30℃。结果:薄层色谱斑点分离较好

斑点清晰;高良姜素在0.104～1.044μg呈线性关系

r=0.999 3

平均回收率98.05%

RSD 1.96%（n=6）;山奈素在（2.2～21.6）ng内呈线性关系

r=0.999 2

平均回收率99.71%

RSD 1.86%（n=6）。结论:该方法简便快速

准确可靠

专属性强

可作为高良姜配方颗粒的质量控制方法。

Abstract

Objective:To explore the quality control standard of Alpinia officiarum Formula Granules and to provide reference for it.Method: TLC was used to identify Alpinia officiarum Formula Granules in different bat-ches.HPLC was used for the determination of galangin and kaempferol.The chromatographic column was phenome-nex Gemini C18（4.6 mm × 250 mm

5 μm）;the mobile phases were methanol-0.4% phosphoric acid（58∶ 42）;the detection wavelength was set at 360 nm;the flow rate was at 1.0 mL.min-1 and the column temperature was at 30 ℃ respectively.Result: The TLC spots were clear and well divided.Galangin was linear in the range of（0.104 ～ 1.044）μg

r = 0.999 3

and the average recovery was 98.05% with RSD = 1.96%（n = 6）;Kaempferol was also linear in the range of（2.2 ～ 21.6）ng

r = 0.999 2

and the average recovery was 99.71% with RSD 1.86%（n = 6）.Conclusion: This method can be used as a quality control standards for Alpinia officiarum Formula Granules.

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