Studies on the quality standard of huanglianjiedu hydrogel

ZHANG Wei-hua1; NIE Qi-xia2; ZHANG Bao-xian2

doi:10.13422/j.cnki.syfjx.2010.04.029

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Studies on the quality standard of huanglianjiedu hydrogel

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- Studies on the quality standard of huanglianjiedu hydrogel
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 4, Pages: 56-59(2010)
- 作者机构：
  
  1. 北京因科瑞斯生物制品研究所
  2. 中国中医科学院中药研究所
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.04.029
  CLC： R286.0
- Published：2010
- 稿件说明：
移动端阅览
[1]张卫华,聂其霞,张保献.黄连解毒凝胶的定量方法研究[J].中国实验方剂学杂志,2010,16(04):56-59.

ZHANG Wei-hua1, NIE Qi-xia2, ZHANG Bao-xian2. Studies on the quality standard of huanglianjiedu hydrogel[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(4): 56-59.
[1]张卫华,聂其霞,张保献.黄连解毒凝胶的定量方法研究[J].中国实验方剂学杂志,2010,16(04):56-59. DOI： 10.13422/j.cnki.syfjx.2010.04.029.

ZHANG Wei-hua1, NIE Qi-xia2, ZHANG Bao-xian2. Studies on the quality standard of huanglianjiedu hydrogel[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(4): 56-59. DOI： 10.13422/j.cnki.syfjx.2010.04.029.

摘要

目的:建立黄连解毒凝胶的定量方法。方法:采用高效液相色谱法对栀子苷、盐酸小檗碱、黄芩苷进行含量测定;均采用luna C18（4.6 mm×250 mm

5μm）色谱柱;栀子甘流动相乙腈-水（13∶87）;盐酸小檗碱流动相乙腈-0.1MK2HPO4（30∶70）水溶液;黄芩苷流动相甲醇-水-磷酸（47∶53∶0.2）。结果:黄连解毒凝胶中栀子苷平均含量不少于0.4%

平均回收率97.21%

RSD 1.5%;盐酸小檗碱平均含量不低于1.2%

平均加样回收率99.11%

RSD 2.45%;黄芩苷平均含量不低于黄芩苷含量不低于1.40%

平均加样回收率98.74%

RSD 1.60%。结论:该质量标准可较好控制黄连解毒凝胶质量。

Abstract

Objective:To establish the quality standard of Huanglianjiedu Hydrogel.Method: The high performance liquid chromatography was developed for the determination the contention of jasminoidin

berberine and baicalin;Luna C18 column（4.6 mm × 250 mm

5 μm） was used in the determination and the mobile phase of jasminoidin

berberine and baicalin were a mixture of acetonitrile-water（13 ∶ 87）

acetonitrile-0.1 mol.L-1 K2HPO4（30∶ 70）

and methanol-water-phosphoric acid（47∶ 53∶ 0.2） respectively.Result: The average content of jasminoidin was no less than 0.4%

and the average recovery and RSD were 97.21% and 1.5% respectively;The average content of berberine was no less than 1.2%

and average recovery and RSD were 99.11% and 2.45% respectively;The average content of jasminoidin was no less than 1.4%

and the average recovery and RSD were 98.74% and 1.6% respectively;Conclusion: This method can be adopted as a standard for the quality control of Huanglianjiedu Hydrogel.

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Related Author

ZHANG Wei-hua

NIE Qi-xia

ZHANG Bao-xian

HAO Cheng-yi

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FENG Bo

WANG Hou-wei

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Related Institution

Department of Pharmacy,First Affiliated Hospital of PLA General Hospital

School of Traditional Chinese Medicine,Capital Medical University

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences

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The First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine

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