The effect on antipyretic and Anti-inflammatory of Qingk-ailing Ingection processed by ultrafiltration

JIANG Cui-lian1; SUN Jian-ning2; ZHANG Shuo-feng2; WU Jing-ying2; JIA Zhan-hong2

doi:10.13422/j.cnki.syfjx.2010.04.043

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The effect on antipyretic and Anti-inflammatory of Qingk-ailing Ingection processed by ultrafiltration

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- The effect on antipyretic and Anti-inflammatory of Qingk-ailing Ingection processed by ultrafiltration
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 4, Pages: 105-108(2010)
- 作者机构：
  
  1. 北京中医药大学药厂
  2. 北京中医药大学中药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.04.043
  CLC： R285.5
- Published：2010
- 稿件说明：
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[1]姜翠莲,孙建宁,张硕峰,吴金英,贾占红.超滤工艺清开灵注射液解热抗炎作用研究[J].中国实验方剂学杂志,2010,16(04):105-108.

JIANG Cui-lian1, SUN Jian-ning2, ZHANG Shuo-feng2, et al. The effect on antipyretic and Anti-inflammatory of Qingk-ailing Ingection processed by ultrafiltration[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(4): 105-108.
[1]姜翠莲,孙建宁,张硕峰,吴金英,贾占红.超滤工艺清开灵注射液解热抗炎作用研究[J].中国实验方剂学杂志,2010,16(04):105-108. DOI： 10.13422/j.cnki.syfjx.2010.04.043.

JIANG Cui-lian1, SUN Jian-ning2, ZHANG Shuo-feng2, et al. The effect on antipyretic and Anti-inflammatory of Qingk-ailing Ingection processed by ultrafiltration[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(4): 105-108. DOI： 10.13422/j.cnki.syfjx.2010.04.043.

摘要

目的:探讨超滤工艺对清开灵注射液解热抗炎作用的影响。方法:以解热、抗炎为主要药效学指标

观察不同剂量超滤工艺产品和原工艺产品对大肠杆菌内毒素（LPS）致家兔体温升高的抑制作用

对角叉菜胶致大鼠足跖肿胀急性炎症的影响

以及对大鼠棉球肉芽肿慢性炎症的影响。结果:超滤工艺组和原工艺组在LPS致热1 h后即表现出显著解热作用

与模型组比较有显著性差异

超滤工艺组P<0.01

原工艺组P<0.05

组间无显著性差异;超滤工艺各组和原工艺大剂量组在致炎后2 h有明显抑制大鼠足跖肿胀的作用

与模型组比较

有显著性差异

P<0.05

组间无显著性差异;剂量为14 mL.kg-1超滤工艺组和同等剂量原工艺组棉球湿重与模型组比较

具有显著性差异

P<0.01

P<0.05

棉球干重组间有极显著性差异

P<0.01。结论:超滤工艺制备的清开灵注射液与原工艺产品比较

解热抗炎作用相似

在抑制棉球肉芽肿慢性炎症方面比原工艺产品显示出更强的作用

提示超滤工艺基本可行。

Abstract

Objective:To study the effect on antipyretic and anti-inflammatory of Qingkailing Ingection（QKL） processed by ultrofiltration（UF）.Method: By using antipyretic and anti-inflammatory as the major pharmacodynamic indicators

to investigate the effect of QKL on inhibition of rabbit increasing temperature induced by LPS

of rat hind paw edema induced by carrageenan and of rat cotton ball granuloma.Result:Both the group of QKL processed by UF and the group of original procedure have obvious effect on antipyretic after 1 hour.Compared with model group

P < 0.01

P < 0.05;They have obvious effect on anti-inflammatory after 2 hour.Compared with model group

P < 0.05

There is no significant difference between the two groups;14 mL.kg-1 dose group of QKL processed by UF and group of original procedure have inhibition of proliferative inflammation.Compared with model group

P < 0.01

P < 0.05

There is significant difference on dry weight of cotton balls between the two groups

P < 0.01.Conclusion:Compared with QKL processed by original procedure

QKL processed by UF has similar action of antipyretic and anti-inflammatory

to some extent

stronger effects.

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The effect on antipyretic and Anti-inflammatory of Qingk-ailing Ingection processed by ultrafiltration

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JIANG Cui-lian

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