TIAN De-zeng, ZHANG Yong-xuan, WEI Xiao-hua, et al. Short term effects of berberine on T2DM resistance to external insulin[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(4): 174-175.
TIAN De-zeng, ZHANG Yong-xuan, WEI Xiao-hua, et al. Short term effects of berberine on T2DM resistance to external insulin[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(4): 174-175. DOI: 10.13422/j.cnki.syfjx.2010.04.062.
Short term effects of berberine on T2DM resistance to external insulin
摘要
目的:观察黄连素对存在外源胰岛素抵抗的2型糖尿病患者血糖的影响
并探索其机制。方法:对外源性胰岛素抵抗的患者加用黄连素
监测空腹、餐后2 h血糖
调整药物用量
35 d后测定空腹胰岛素水平
用HOMA公式计算胰岛素抵抗指数。结果:黄连素对全部患者黄连素均有效
14 d起效
21 d达最佳效果
35 d可减将胰岛素减少30%。结论:黄连素可能通过增加胰岛素的敏感性
而改善外源性胰岛素抵抗。
Abstract
Objective: To observe the effects of berberine on T2DM resistance to external insulin and machine.Method:Berberine were given to patients with T2DM and resistant to external insulin and the dose was adjusted with FBG and 2hPG levels.Then fasting insulin level were determined after 35day and insulin resistance rate was calculated by HOMA formula.Result:All patient were effectively reacting to berberine since the14th day and it was the most obvious at the 21 th day.The dose of insulin was decreased by 30 percent at the 35 th day.Conclusion:Berberine can improve T2DM resistance to external insulin by increasing T2DM insulin sensibility.
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Related Author
TIAN De-zeng
ZHANG Yong-xuan
WEI Xiao-hua
LIU Ming-zhe
REN Bao-xian
WANG Peng-hu
BU Xiangwei
HAO Xiaohui
Related Institution
Guang'anmen Hospital,China Academy of Chinese Medicine Sciences
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine(TCM)
Shunyi Hospital,Beijing TCM Hospital
Research Center for Differentiation and Development of Traditional Chinese Medicine (TCM) Basic Theory, Jiangxi Province Key Laboratory of TCM Etiopathogenisis, Jiangxi University of Chinese Medicine