A Clinical Study on A Randomized,Double-blind Controlled of ShuYu Capsule in Patients with Vascular Depresion

LI Le-jun; SHAO Fen-yang; XIAO Hui; LIU Xiao-li; ZHOU Yong-yuan; XU Yun-tang

doi:10.13422/j.cnki.syfjx.2010.05.005

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A Clinical Study on A Randomized,Double-blind Controlled of ShuYu Capsule in Patients with Vascular Depresion

更新时间：2024-09-23

- A Clinical Study on A Randomized,Double-blind Controlled of ShuYu Capsule in Patients with Vascular Depresion
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 5, Pages: 220-223(2010)
- 作者机构：
  
  1. 江苏省连云港市中医院脑血管科
  2. 2. 南京中医药大学连云港附属医院脑血管科
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.05.005
  CLC： R277.7
- Published：2010
- 稿件说明：
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[1]李乐军,邵凤扬,肖辉,刘晓丽,周永媛,许运堂.舒郁胶囊治疗血管性抑郁患者随机双盲对照临床研究[J].中国实验方剂学杂志,2010,16(05):220-223.

LI Le-jun, SHAO Fen-yang, XIAO Hui, et al. A Clinical Study on A Randomized,Double-blind Controlled of ShuYu Capsule in Patients with Vascular Depresion[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 220-223.
[1]李乐军,邵凤扬,肖辉,刘晓丽,周永媛,许运堂.舒郁胶囊治疗血管性抑郁患者随机双盲对照临床研究[J].中国实验方剂学杂志,2010,16(05):220-223. DOI： 10.13422/j.cnki.syfjx.2010.05.005.

LI Le-jun, SHAO Fen-yang, XIAO Hui, et al. A Clinical Study on A Randomized,Double-blind Controlled of ShuYu Capsule in Patients with Vascular Depresion[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 220-223. DOI： 10.13422/j.cnki.syfjx.2010.05.005.

摘要

目的:观察舒郁胶囊对血管性抑郁（vascular depresion

VD）患者的临床疗效。方法:对各组试验药进行盲法要求包装

采用随机、双盲、阳性平行对照法共观察60例VD患者。治疗组30例

服用舒郁胶囊

每次3粒

每日3次

同时服氟西汀胶囊安慰剂每次1粒

每日1次;对照组30例

服用氟西汀胶囊每次1粒

每日1次

同时服舒郁胶囊安慰剂每次3粒

每日3次

连续治疗

两组总疗程均为8周。于服药前、服药4周、8周后分别进行神经心理学量表评价和血脂检测分析。结果:采用舒郁胶囊能降低治疗前后HAMD、MMSE、CGI评分

两组间比较HAMD、MMSE、CGI的评分差异有统计学意义（P<0.05）;同时也能降低治疗组治疗8周后NDS评分及血LDL-C水平（P<0.05）

但对对照组NDS评分及血LDL-C水平改善不明显（P>0.05）。对两组治疗总有效率比较差异无统计学意义（P>0.05）。结论:舒郁胶囊治疗血管性抑郁有较好临床疗效

与氟西汀胶囊治疗效果相当。

Abstract

Objective:To evaluate the effectiveness of ShuYu Capsule in patients with vascular depresion （VD）. Method: The investigational drugs were packed by blind method. A randomized

double-blind and controlled trial was conducted on sixty patients with VD. The sixty patients were randomly divided into treatment group （n = 30）

orally ShuYu Capsule 3# tid and Fluoxetine capsule placebo 20mg qd

for 8 wk. and control group （n = 30）

orally Fluoxetine capsule 20mg qd

and ShuYu Capsule placebo 3 # tid

for 8 wk. All subjects were assessed by HAMD

MMSE

CGI

NDS and Blood lipids. Result: ShuYu Capsule can be reduced the scores of HAMD

MMSE

CGI of Before and after treatment

The difference has statistics meaning （ P < 0. 05） between two groups; Can reduce the NDS grading and blood LDL-C level （ P < 0. 05） after 8 w in treatment group

But NDS grade and the blood LDL-C level can not be improved obviously （ P > 0. 05） in control group. Have not statistics significantly （ P > 0. 05 ） in the always efficient comparative difference between two groups of treatment. Conclusion: ShuYu Capsule has better clinical effect in vascular depresion

equal effect to Fluoxetine capsule.

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