Influence of a Chinese Herbal Compound Granule with Functions of Cooling and Promoting Blood Circulation on Coagulation Function and Whole Blood Viscosity in Rats with Radiation-induced Lung Injury

XIAO Chun1; YANG Xu-hui2; LIU Yi2; DOU Yong-qi1

doi:10.13422/j.cnki.syfjx.2010.05.013

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Influence of a Chinese Herbal Compound Granule with Functions of Cooling and Promoting Blood Circulation on Coagulation Function and Whole Blood Viscosity in Rats with Radiation-induced Lung Injury

更新时间：2024-09-23

- Influence of a Chinese Herbal Compound Granule with Functions of Cooling and Promoting Blood Circulation on Coagulation Function and Whole Blood Viscosity in Rats with Radiation-induced Lung Injury
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 5, Pages: 103-106(2010)
- 作者机构：
  
  解放军总医院全军中医研究所
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.05.013
  CLC： R285.5
- Published：2010
- 稿件说明：
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[1]肖春,杨旭辉,刘毅,窦永起.凉血活血颗粒对放射性肺损伤大鼠凝血功能及全血黏度指标的影响[J].中国实验方剂学杂志,2010,16(05):103-106.

XIAO Chun1, YANG Xu-hui2, LIU Yi2, et al. Influence of a Chinese Herbal Compound Granule with Functions of Cooling and Promoting Blood Circulation on Coagulation Function and Whole Blood Viscosity in Rats with Radiation-induced Lung Injury[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 103-106.
[1]肖春,杨旭辉,刘毅,窦永起.凉血活血颗粒对放射性肺损伤大鼠凝血功能及全血黏度指标的影响[J].中国实验方剂学杂志,2010,16(05):103-106. DOI： 10.13422/j.cnki.syfjx.2010.05.013.

XIAO Chun1, YANG Xu-hui2, LIU Yi2, et al. Influence of a Chinese Herbal Compound Granule with Functions of Cooling and Promoting Blood Circulation on Coagulation Function and Whole Blood Viscosity in Rats with Radiation-induced Lung Injury[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 103-106. DOI： 10.13422/j.cnki.syfjx.2010.05.013.

摘要

目的:观察凉血活血颗粒对放射性肺损伤大鼠凝血功能及全血黏度的影响。方法:90只雄性Wistar大鼠

随机分为空白对照组、模型组、凉血活血颗粒治疗组

每组30只

模型组及治疗组大鼠用6MVX线右胸一次性照射25Gy造模。造模前1周开始各组分别ig凉血活血颗粒或生理盐水

每日1次。在照射后7d

30d

90d

每组处死10只

行肺组织HE染色

腹主动脉取抗凝血检测凝血4项及全血黏度指标。结果:模型组照射后出现放射性肺炎及纤维化表现

治疗组炎症及纤维化表现较模型组明显减轻。模型组大鼠在照射后7d

出现高凝、高黏改变;在放射后30d

出现低凝、低黏改变;在放射后90d出现低凝、高黏改变。治疗组大鼠在照射后7d

凝血时间延长

血液黏度减低;在照射后30d

凝血时间缩短

血液黏度升高;在放射后90d

凝血时间缩短

全血黏度降低。结论:放射性肺损伤存在凝血功能紊乱及血液黏度异常

凉血活血颗粒对上述情况具有调节作用

能减轻放射性肺损伤的严重程度。

Abstract

Objective:To object the influence of a Chinese herbal compound granule with functions of cooling and promoting blood circulation on coagulation function and whole blood viscosity in rats with radiationinduced lung injury. Method:Ninety male wistar rats were randomly assigned to blank group

model group and treatment group with 30 rats in each group. The rats in model and treatment group were irradiated with 6 MV x-rays

25Gy /fraction in the right lung and were given saline or Chinese herbal compound granule accordingly. The rats in blank group were given saline without radiation. Ten rats in each group were sacrificed at the time of 7 d

30 d and 90 d after radiation. The tissue pathology was conducted; Whole blood viscosity and coagulation indexes were evaluated. Result:The rats in model group developed radiation pneumonitis and fibrosis. The pathological changes of radiation injury in treatment group were slighter than the model group. The rats in model group were in the high coagulation and viscosity state in 7 d

in the low coagulation and viscosity state in 30 d

in the low coagulation and high viscosity state in 90 d. The coagulation time in the treatment group was longer in 7 d

shorter in 30 d and 90 d;The whole blood viscosity was decreased in 7 d

increased in 30 d

decreased in 90 d. Conclusion: Blood coagulation function disorder and viscosity abnormality occurred in the radiation-induced lung injury. The herbal compound granule with functions of cooling and promoting blood circulation can make appropriate adjustment and reduce the radiation-induced lung injury.

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Related Author

LIU Yi

DOU Yong-qi

YANG Xu-hui

XIAO Chun

LU Tingting

WANG Yu

ZHANG Lu

TANG Leilei

Related Institution

School of Integrated Chinese and Western Medicine，Anhui University of Chinese Medicine

The First Affiliated Hospital of Anhui University of Chinese Medicine

Key Laboratory of Xin'an Medicine， Ministry of Education， Anhui University of Chinese Medicine

Institute of Traditional Chinese Medicine Respiratory Disease Prevention and Treatment， Anhui Academy of Chinese Medicine

The First School of Clinical Medicine， Nanjing University of Chinese Medicine

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