Effect of PRD Ultramicro-powder on the Indexes Correlated with Glycometabolism in Obese Type 2 Diabetes Mellitus Rats

PANG Zong-ran1; ZHAO Yu-tang2; LI Jing-hua2; LIU Zu-han1; LI Xiao-jun2; CAO Shi-li3; ZHANG Bo-li3

doi:10.13422/j.cnki.syfjx.2010.05.014

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Effect of PRD Ultramicro-powder on the Indexes Correlated with Glycometabolism in Obese Type 2 Diabetes Mellitus Rats

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- Effect of PRD Ultramicro-powder on the Indexes Correlated with Glycometabolism in Obese Type 2 Diabetes Mellitus Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 5, Pages: 107-110(2010)
- 作者机构：
  
  1. 中央民族大学中国少数民族传统医学研究院
  2. 承德医学院
  3. 天津中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.05.014
  CLC： R285.5
- Published：2010
- 稿件说明：
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[1]庞宗然,赵玉堂,李静华,刘祖涵,李晓军,曹式丽,张伯礼.菩人丹超微粉对肥胖型2型糖尿病大鼠糖代谢相关指标的影响[J].中国实验方剂学杂志,2010,16(05):107-110.

PANG Zong-ran1, ZHAO Yu-tang2, LI Jing-hua2, et al. Effect of PRD Ultramicro-powder on the Indexes Correlated with Glycometabolism in Obese Type 2 Diabetes Mellitus Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 107-110.
[1]庞宗然,赵玉堂,李静华,刘祖涵,李晓军,曹式丽,张伯礼.菩人丹超微粉对肥胖型2型糖尿病大鼠糖代谢相关指标的影响[J].中国实验方剂学杂志,2010,16(05):107-110. DOI： 10.13422/j.cnki.syfjx.2010.05.014.

PANG Zong-ran1, ZHAO Yu-tang2, LI Jing-hua2, et al. Effect of PRD Ultramicro-powder on the Indexes Correlated with Glycometabolism in Obese Type 2 Diabetes Mellitus Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 107-110. DOI： 10.13422/j.cnki.syfjx.2010.05.014.

摘要

目的:观察菩人丹超微粉（PRD supermicropowder）对2型糖尿病（Type 2 diabetes mellitus

T2DM）大鼠血糖、糖耐量、糖化血清蛋白、血清胰岛素及胰岛素敏感指数的影响

探讨菩人丹的降糖作用。方法:采用大鼠灌胃脂肪乳

辅以尾静脉快速iv小剂量链脲佐菌素

制备以胰岛素抵抗为特征的T2DM合并大血管病变的动物模型。成模大鼠随机分为菩人丹低、中、高治疗组

马来酸罗格列酮治疗组

模型组

各组分别ig给予相应药物治疗4周

测定用药前、用药后2周、4周大鼠随机血糖和治疗4周末空腹血清胰岛素、糖化血清蛋白含量

计算胰岛素敏感指数。结果:模型大鼠随机血糖和糖化血清蛋白含量较正常组上调

血清胰岛素、胰岛素敏感指数明显降低（P<0.01）。菩人丹低

中

高剂量及马来酸罗格列酮治疗组均能显著降低大鼠随机血糖和糖化血清蛋白含量（P<0.05～0.01）

菩人丹中、高剂量组及马来酸罗格列酮组显著升高T2DM模型大鼠血清胰岛素含量（P<0.05～0.01）

提高胰岛素敏感指数（P<0.05～0.01）。结论:菩人丹超微粉可降低T2DM大鼠过高的血糖和糖化血清蛋白含量

增加胰岛素敏感性

从而改善T2DM大鼠糖代谢。

Abstract

Objective:To observe the influence of PRD（Pu Ren Dan） ultramicro-powder on the functional indexes correlated with glycometabolism in T2DM rats

including plasma glucose

glucose tolerance

glycosylated serum protein

serum insulin and insulin sensitivity index. And to investigate the hypoglycemic effect of PRD. Method: Wistar rats were fed fat milk

and small doses of streptozotocin was rapidly injected into tail vein. Animal models of type 2 diabetes with macroangiopathy characterized by insulin resistance were successfully prepared in a short time. The model rats were randomly divided into five groups including PRD low dose

PRD medium dose

PRD high dose

rosiglitazone maleate and model groups. Every group was respectively treated for 4 weeks with PRD low dose

PRD medium dose

PRD high dose

rosiglitazone maleate and water. Random plasma glucose of rats were respectively measured before treatment

after 2 weeks and 4 weeks with treatment. Fasting serum insulin and glycosylated serum protein content of rats were measured on the 4th weekend. And Insulin sensitivity index were calculated. Result:As compared with normal group rats

random plasma glucose and glycosylated serum protein content of model group rats were increased

while serum insulin and insulin sensitivity index significantly were decreased（P < 0. 01）. Random plasma glucose and glycosylated serum protein content of rats were all significantly reduced in PRD low

medium

high dose and rosiglitazone maleate groups （ P < 0. 05 ～ 0. 01 ）. Serum insulin content and insulin sensitivity index of T2DM model rats treated by PRD medium

high dose and rosiglitazone maleate were significantly increased（ P < 0. 05 ～ 0. 01）. Conclusion:Based on reducing the high level of plasma glucose and glycosylated serum protein content

PRD ultramicro-powder can enhance insulin sensitivity of T2DM rats and improve glycometabolism in T2DM rats.

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Related Author

PANG Zong-ran

ZHAO Yu-tang

LI Jing-hua

LIU Zu-han

LI Xiao-jun

CAO Shi-li

ZHANG Bo-li

QIN Yang

Related Institution

Key Laboratory of Modern Chinese Medicine Formulations of Jiangxi University of Chinese Medicine， Ministry of Education

School of Pharmacy， Jiangxi University of Chinese Medicine

National Key Laboratory of Creation of Modern Chinese Medicine with Classical Formulas

Dongfang Hospital， Beijing University of Chinese Medicine

Key Laboratory of Health Preservation and Rehabilitation， Ministry of Education， Beijing University of Chinese Medicine

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