ZHANG Ying-feng, ZHOU Li-ling. The Pharmacokinetics Study of Sinomenine Transdermal Patch on Rats Arthritis Model Induced by Freund’s Adjuvant[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 123-126.
ZHANG Ying-feng, ZHOU Li-ling. The Pharmacokinetics Study of Sinomenine Transdermal Patch on Rats Arthritis Model Induced by Freund’s Adjuvant[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 123-126. DOI: 10.13422/j.cnki.syfjx.2010.05.019.
The Pharmacokinetics Study of Sinomenine Transdermal Patch on Rats Arthritis Model Induced by Freund’s Adjuvant
摘要
目的:研究青藤碱贴剂在病理状态下的药动学规律。方法:以佐剂性关节炎大鼠为研究对象
以HPLC-UV为检测手段
测定给药以后不同时间点的血药浓度
计算药动学参数。结果:建立了专属性的血药浓度检测方法
青藤碱贴剂达峰时间约10h
MRT约24h
达峰浓度约455ng/mL
其体内行为属于一级速率、二室开放模型。结论:该方法灵敏、快速、正确、选择性强
较好的满足青藤碱的药动学研究
为合理用药提供参考。
Abstract
Objective: To explore the pharmacokinetic of Sinomenine transdermal patch. Method: The plasma drug concentration of rats arthritis model induced by Freund’s adjuvant was determined after administration with HPLC-UVD as analysis tools. The pharmacokinetics parameters was fitted with kinetica software package. Result: The exclusive analysis method was established with the following pharmacokinetics parameters: T(peak) = 10 h
Cmax = 455 ng /mL
MRT = 24 h. The pharmacokinetic characteristics was accordance with one-order rate and two – compartment model. Conclusion:The method is suitable to be applied to the pharmacokinetics research and further applied pharmacological study which will play a reference role in clinical application.