TANG Xi-lan1, XU Guo-liang1, LI Bing-tao1, et al. Metabonomics Study on the Urine in Rat Treated by Water Extract of Zanthoxylumschinifolium Siebet Zucc[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 127-131.
TANG Xi-lan1, XU Guo-liang1, LI Bing-tao1, et al. Metabonomics Study on the Urine in Rat Treated by Water Extract of Zanthoxylumschinifolium Siebet Zucc[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 127-131. DOI: 10.13422/j.cnki.syfjx.2010.05.020.
Metabonomics Study on the Urine in Rat Treated by Water Extract of Zanthoxylumschinifolium Siebet Zucc
Objective:HPLC/MS/MS-based study on the changes of endogenous metabolites of Sprague-Dawley Rats administrated with water extract of Zanthoxylumschinifolium Siebet Zucc. Method:Ten Sprague-Dawley rats were successively administrated with Zanthoxylumschinifolium Siebet Zucc water extract (0. 342 8 g·kg -1 ) for 30 days. Agilent1200 6410 Triple Quadrupole mass spectrometer was used for the analysis of endogenous metabolites in rat urine samples. These data were analyzed by OSC-PLS-DA. Result: The difference in metabolic profiles between the control group and the dosed group was well observed by OSC-PLS-DA analysis after administration of 15 days
31 biomarkers were found
such as cytidine
decanoylcarnitine and N-acetylglucosamine 6-phosphate. Conclusion:The administration of Zanthoxylumschinifolium Siebet Zucc water extract could influence concentrations of endogenous matabolites related to anticancer
analgesic and hypolipidemic pharmacological actions. This work can provide basis for further researches on the interpretation of drug property of evodiae.
Metabonomics Study on the Urine in Rat Treated by Water Extract of
Detection of Serum Metabolites After Intragastric Administration of Guizhi Decoction in Rats by Nuclear Magnetic Resonance Metabonomics
Detection of Rats' Urine Biomarkers of Aconitine Poisoning by UPLC/Q-TOF Mass Spectrometry
Analysis of Urine Metabonomics of Nephrotic Syndrome Rats Treated with Compatibility of Tripterygii Wilfordii Radix et Rhizoma and Glycyrrhizae Radix et Rhizoma Based on UPLC-Q-TOF-MS