The Preparation of Compound Danshen Pellets by Using Centrifugal Granulator

YUAN Liang1; ZHANG Jian-qin3; LIN Ting-ting1; ZHANG Guo-song2; SUN Sha-sha1; GUAN Yang1; LUO Xiao-jian1

doi:10.13422/j.cnki.syfjx.2010.05.053

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The Preparation of Compound Danshen Pellets by Using Centrifugal Granulator

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- The Preparation of Compound Danshen Pellets by Using Centrifugal Granulator
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 5, Pages: 10-14(2010)
- 作者机构：
  
  1. 江西中医学院
  2. 江西仁丰药业有限公司
  3. 中药固体制剂制造技术国家工程研究中心
  4. 药固体制剂制造技术国家工程研究中心
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.05.053
  CLC： R287
- Published：2010
- 稿件说明：
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[1]袁亮,张建琴,林婷婷,张国松,孙莎莎,官扬,罗晓健.离心造粒法制备复方丹参微丸[J].中国实验方剂学杂志,2010,16(05):10-14.

YUAN Liang1, ZHANG Jian-qin3, LIN Ting-ting1, et al. The Preparation of Compound Danshen Pellets by Using Centrifugal Granulator[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 10-14.
[1]袁亮,张建琴,林婷婷,张国松,孙莎莎,官扬,罗晓健.离心造粒法制备复方丹参微丸[J].中国实验方剂学杂志,2010,16(05):10-14. DOI： 10.13422/j.cnki.syfjx.2010.05.053.

YUAN Liang1, ZHANG Jian-qin3, LIN Ting-ting1, et al. The Preparation of Compound Danshen Pellets by Using Centrifugal Granulator[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 10-14. DOI： 10.13422/j.cnki.syfjx.2010.05.053.

摘要

目的:制备复方丹参微丸。方法:采用离心造粒法

以微丸粒径分布、休止角、堆密度、脆碎度等为指标考察影响微丸成型过程的处方因素和工艺因素。结果:复方丹参微丸成型的优化处方为:冰片-β环糊精包合物与稀释剂MCC重量比为4∶3（g∶g）

以40%糖浆（含丹参三七混合物）作为黏合剂。采用离心造粒法

工艺参数如下:主机转速200r·min-1、鼓风流量8L·min-1、喷气流量18L·min-1、喷气压力0.06Mpa、喷浆泵转速12～17r·min-1、供粉机转速15～20r·min-1。复方丹参微丸在15min内的体外溶出度达到85%以上。结论:采用离心造粒法在优化条件下可制得表面较光滑、圆整度高的复方丹参微丸

20～24目微丸的得率达85%以上

3种指标成分体外溶出迅速且同步性良好。

Abstract

Objective:To prepare compound Danshen pellets. Method: The compound Danshen pellets were prepared by using a centrifugal granulator. The composition and process factors were optimized by adopting several indices such as sphericity of pellets

repose angle

bulk density and friability. Result: The optimal process parameters were as follows:the quality ratio of Borneol-β-Cyclodextrinclusion Complexes and MCC was 4∶ 3

binder solvent was 40% syrup

which including extractive. The rotating rate of plate was 200 r·min -1

the blower rate was 8L·min -1

the rate of air flow was 18 L·min -1

the spray air pressure was 0. 06 MPa

the rotating rate of spray solution pump was 12 ～ 17 r·min -1 and the rotating rate of powder feed machine was 15 ～ 20 r·min -1. The active components could release more than 85% in 15 minutes. Conclusion: Under the optimal conditions

the compound Danshen pellets prepared by using the centrifugal granulator have prefect shape and surface characteristics

the yield of target size pellets are more than 85% . The three index components could release fast and synchronically.

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