CUI Qin-rong1, AN Xiao-ping2, KANG Xue-dong2, et al. Effects of Huangjin Capsule on Enhancing Insulin Sensitivity in Type 2 Diabetic-insulin Resistant Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 150-152.
CUI Qin-rong1, AN Xiao-ping2, KANG Xue-dong2, et al. Effects of Huangjin Capsule on Enhancing Insulin Sensitivity in Type 2 Diabetic-insulin Resistant Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 150-152. DOI: 10.13422/j.cnki.syfjx.2010.05.055.
Effects of Huangjin Capsule on Enhancing Insulin Sensitivity in Type 2 Diabetic-insulin Resistant Rats
Objective:To investigate the effects of Huangjin capsule on insulin sensitivity in type 2 diabetic rats with insulin-resistance ( IR) and the primary pharmacological mechanism. Method: The model for type 2 diabetic-insulin-resistant rats ( T2DIRR ) were performed through intraperitonea injection of lower dosage of streptozocin(30 mg /kg) and high caloric diet ( abounded with sugar & fat). The effects of Huangjin on weight
blood and /or serum contents of glucose
lipids
insulin and insulin sensitive index(ISI) were observed in the model rats. Result: Huangjin lowered significantly fasting blood glucose ( FBG) ( P < 0. 05 ) and improved impaired glucose tolerance (IgT); and reduced the concentration of insulin in hyperinsulinemia
and potentiated ISI ( P < 0. 01) in T2DIRR. Conclusion: In the experiment with type 2 diabetic-insulin-resistantrats