LI Yan1, CUI Nai-qing2. Effect of Qingyi Granule with Lung Injury Caused by Severe Acute Pancreatits in Clinical Research[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 250-252.
LI Yan1, CUI Nai-qing2. Effect of Qingyi Granule with Lung Injury Caused by Severe Acute Pancreatits in Clinical Research[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 250-252. DOI: 10.13422/j.cnki.syfjx.2010.06.013.
Effect of Qingyi Granule with Lung Injury Caused by Severe Acute Pancreatits in Clinical Research
Objective:To explore the preventive and therapeutic effects of Qingyi granule on the lung injury induced by severe acute pancreatitis(SAP).Method:SAP consists of 58 patients with combination therapy group(n = 32)and conventional western medicine treatment group(n = 26).The two groups were observed in patients with abdominal pain and ease the time
peristaltic recovery time
time to correct hypoxemia
treatment before and 72 h after treatment of blood endotoxin(ET)
tumor necrosis factor-α(TNF-α)
interleukin-6(IL-6) levels of change and re-line upper abdominal spiral CT scan assessment of the progress of pancreatitis patients.Result:The combination therapy group treated with conventional Western medicine incidence of hypoxemia were 43.75%
76.92%(P < 0.05);ARDS incidence rate of 9.38%
respectively
34.62%(P < 0.05);treatment 72 h after the combination therapy group of blood ET
TNF-α
IL-6 than conventional western medicine treatment group blood ET
TNF-α
IL-6 levels were significantly decreased(P < 0.05);in the combination therapy group the time to ease abdominal pain
bowel recovery time
hypoxemia corrected time
CT scan shows the extent of progress of pancreatitis was significantly lower than the proportion of conventional western medicine treatment group(P < 0.05).Conclusion:Qingyi particles through the protection of the intestinal barrier
reducing bacterial translocation
lower serum endotoxin
TNF-α
IL-6 and other inflammatory mediators
and correct the body imbalance between proinflammatory and anti-inflammatory system
and many other mechanisms of play a role in the comprehensive protection of the lungs.
Effect of Qingyi Granule with Lung Injury Caused by Severe Acute Pancreatits in Clinical Research
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Related Author
LI Yan
CUI Nai-qing
ZHAO Jie
LIN Xiaojie
WEN Xianan
ZENG Qiaolin
WANG Li
ZHENG Yuanru
Related Institution
School of Health Science,Guangdong Pharmaceutical University
College of Pharmacy,Guangzhou Health Science College
School of Pharmacy,Guangdong Pharmaceutical University
Henan University of Chinese Medicine
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences