ZHANG Jian-min, CHEN Xiao-qiong, JIANG San-yuan, et al. Preparation Quality Control and Clinical Efficacy of Huachangtongbian Tablets[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 30-32.
ZHANG Jian-min, CHEN Xiao-qiong, JIANG San-yuan, et al. Preparation Quality Control and Clinical Efficacy of Huachangtongbian Tablets[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 30-32. DOI: 10.13422/j.cnki.syfjx.2010.06.022.
Preparation Quality Control and Clinical Efficacy of Huachangtongbian Tablets
quality control and clinical efficacy of Huachangtongbian Tablets.Method:The TLC
HPLC were used for the identification and characterization of Chinese herbal medicines preparation and determination of chrysophanol respectively;The antitheses was used in the clinical observation.Result:The preparation technology is feasible.Clear spots were noted in the TLC of Cassia occidentalis and rhubarb;Chrysophanol was linear in the range of 0.016 ~ 0.24 μg(r = 0.999 7) with the maximum absorption at 413nm.The average recovery was 98.25%(RSD 1.40%
n = 6);125 cases with habitual constipation were used in clinical observation.The total effectiveness in the treatment group was 92.0%
significantly better than 76.0% in the control group.Conclusion:The preparation formula is reasonableand the technology is feasible.TLC and HPLC methods can be used in the quality control of the preparation
with which better clinical efficacy was observed and no adverse reactions occured.
Shandong Technical Innovation Center for Traditional Chinese Medicine Treatment of Respiratory Diseases,Shandong Hongjitang Pharmaceutical Group Co. Ltd.
Shandong Institute for Food and Drug Control
School of Pharmacy,State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine