LIN Yan-jun, ZHANG Jin-ming, QU Yan, et al. The Impact of Total Paeony Glycoside on Experimental Gastric Ulcer in Rat Model[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 215-217.
LIN Yan-jun, ZHANG Jin-ming, QU Yan, et al. The Impact of Total Paeony Glycoside on Experimental Gastric Ulcer in Rat Model[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 215-217. DOI: 10.13422/j.cnki.syfjx.2010.06.037.
The Impact of Total Paeony Glycoside on Experimental Gastric Ulcer in Rat Model
Objective:To investigate the therapeutic effect of total paeony glycoside on secretion of gastric juice and serum biochemical indexes for ulcer model in rat
and to reveal the mechanism.Method:Rat gastric ulcer model was established by pyloric ligation
and gastric juice was collected for rats in all groups.The gastric juice volume
total acidity and the activity of pepsin were measured.Nitric oxide(NO) content
superoxide dismutase(SOD) activity and malondialdehyde(MDA) content in rat serum were determined.Result:Total paeony glycoside could inhibit the gastric juice volume
total acidity
the activity of pepsin in the rat model.Furthermore it could significantly increase NO content and SOD activity
and reduce the MDA content in rat serum.Conclusion:The anti-gastric ulcer mechanism of total paeony glycoside is likely achieved by promoting defense factors
The Impact of Total Paeony Glycoside on Experimental Gastric Ulcer in Rat Model
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Related Author
LIN Yan-jun
ZHANG Jin-ming
QU Yan
YOU Yu
LI Jiaze
SHEN Xiaopu
XIANG Xi
GUO Hui
Related Institution
The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine
School of Pharmacy, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine
School of Pharmacy of Anhui University of Chinese Medicine,Anhui Province Key Laboratory of Chinese Medicinal Compounds,Synergetic Innovation Center of Anhui Authentic Chinese Medicine, Heifei
Academy of Traditional Chinese Medicine,Henan University of Chinese Medicine
Li Zhenhua Institute of Academic Thought, Henan University of Chinese Medicine