Protection for Acute Liver Injury in Mice by a Polysaccharide from Salvia miltiorrhiza

YAO Ying-hua; LIU Qiang; CHEN Yu-yao; SUN Xuegang; LV Zhi-ping

doi:10.13422/j.cnki.syfjx.2010.06.041

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Protection for Acute Liver Injury in Mice by a Polysaccharide from Salvia miltiorrhiza

更新时间：2024-09-23

- Protection for Acute Liver Injury in Mice by a Polysaccharide from Salvia miltiorrhiza
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 6, Pages: 227-230(2010)
- 作者机构：
  
  南方医科大学中医药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.06.041
  CLC： R285.5
- Published：2010
- 稿件说明：
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[1]姚莹华,刘强,陈育尧,孙学刚,吕志平.丹参多糖对小鼠急性肝损伤的保护作用[J].中国实验方剂学杂志,2010,16(06):227-230.

YAO Ying-hua, LIU Qiang, CHEN Yu-yao, et al. Protection for Acute Liver Injury in Mice by a Polysaccharide from Salvia miltiorrhiza[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 227-230.
[1]姚莹华,刘强,陈育尧,孙学刚,吕志平.丹参多糖对小鼠急性肝损伤的保护作用[J].中国实验方剂学杂志,2010,16(06):227-230. DOI： 10.13422/j.cnki.syfjx.2010.06.041.

YAO Ying-hua, LIU Qiang, CHEN Yu-yao, et al. Protection for Acute Liver Injury in Mice by a Polysaccharide from Salvia miltiorrhiza[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 227-230. DOI： 10.13422/j.cnki.syfjx.2010.06.041.

摘要

目的:探讨丹参多糖Salvia miltiorrhiza polysaccharides（SMPS）对小鼠急性肝损伤的影响。方法:将小鼠随机分为空白对照组、模型组、丹参多糖高剂量组（15.6 g.kg-1）、丹参多糖中剂量组（7.8 g.kg-1）和丹参多糖低剂量组（3.9 g.kg-1）

连续ig 7 d后

采用尾iv脂多糖（LPS）诱导小鼠急性肝损伤模型

检测各组小鼠肝组织中丙二醛（MDA）、还原型谷胱甘肽（GSH）、血清中谷丙转氨酶（ALT）的活性以及肝组织的病理改变。结果:丹参多糖能降低LPS诱导的急性肝损伤模型小鼠肝组织中MDA含量

升高GSH含量

降低血清ALT含量。结论:丹参多糖对小鼠急性肝损伤有显著的保护作用。

Abstract

Objective:To investigate the protective effects of Salvia miltiorrhiza against acute liver injury induced by lipopolysaccharide（LPS） in mice.Method:Fifty NIH mice were randomly divided into five groups

low-dose（3.9 g.kg-1） of SMPS（SMPS-L）

middle-dose（7.8 g.kg-1） of SMPS（SMPS-M）

and high-dose（15.6 g.kg-1） of SMPS（SMPS-H）were given daily via gavage for a period of 7 days.The control group and model group were given an equal volume of saline.Seven days later

the mice were given LPS（5 mg.kg-1）（control received saline alone） via lateral tail vein injection.Three hours after the injection of LPS

the mice were weighed and the blood was collected from mice orbit.The contents of malondialdehyde（MDA） and glutathione（GSH） in the liver tissue were measured by colorimetric method

and the serum levels of alanine aminotransferase（ALT） was determined.The pathological change of liver was observed using light microscope.Result:SMPS could significantly reduced contend of MDA and the serum levels of ALT

nevertheless the levels of GSH significantly increased.Conclusion:SMPS offers obvious effects on protecting acute liver injury induced by lipopolysaccharide.

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Related Author

YAO Ying-hua

LIU Qiang

CHEN Yu-yao

SUN Xuegang

LV Zhi-ping

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HE Zhanzhan

CHU Ce

Related Institution

West China Clinical Medical College，Sichuan University

Beijing University of Chinese Medicine

Institute of Basic Theory for Chinese Medicine，China Academy of Chinese Medical Sciences

School of Clinical Medicine，Changchun University of Chinese Medicine

School of Pharmacy，Changchun University of Chinese Medicine

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