LI Juan-e, WANG Lei, QIN Ling-ling, et al. A Review on Spontaneous Models of Type 2 Diabetes Mellitus in Rodents[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 267-271.
LI Juan-e, WANG Lei, QIN Ling-ling, et al. A Review on Spontaneous Models of Type 2 Diabetes Mellitus in Rodents[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 267-271. DOI: 10.13422/j.cnki.syfjx.2010.06.044.
A Review on Spontaneous Models of Type 2 Diabetes Mellitus in Rodents
The spontaneous models of T2DM which were successful screened and conserved have been mainly in rodents.The occurrence and development of T2DM in this models is similar to mankinds
so they have important application value in the study of T2DM
such as physiology
pathology and new clinical medicines.Nowdays
these models mainly include signle gene mutation mouse(ob /ob
db /db
KK-ay)
NZO and NSY mouse
GK
OLETF and ZUCKER rats
Psammomys Obesus.In order to improve the application of these models for T2DM
the characteristics of each model about mechanisms
physiology and pathology were described in this article.