Effect of Azone on Transdermal Absorption in vitro of Dieda Huoluo Microemulsion Spray

WANG Li-sheng; LAI Bao-lin; WU Yang; ZHOU Li-ling

doi:10.13422/j.cnki.syfjx.2010.06.060

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Effect of Azone on Transdermal Absorption in vitro of Dieda Huoluo Microemulsion Spray

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- Effect of Azone on Transdermal Absorption in vitro of Dieda Huoluo Microemulsion Spray
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 6, Pages: 26-29(2010)
- 作者机构：
  
  广州中医药大学药剂教研室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.06.060
  CLC： R283.6
- Published：2010
- 稿件说明：
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[1]王利胜,赖宝林,吴阳,周莉玲.氮酮对跌打活络微乳喷雾剂体外透皮吸收影响的研究[J].中国实验方剂学杂志,2010,16(06):26-29.

WANG Li-sheng, LAI Bao-lin, WU Yang, et al. Effect of Azone on Transdermal Absorption in vitro of Dieda Huoluo Microemulsion Spray[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 26-29.
[1]王利胜,赖宝林,吴阳,周莉玲.氮酮对跌打活络微乳喷雾剂体外透皮吸收影响的研究[J].中国实验方剂学杂志,2010,16(06):26-29. DOI： 10.13422/j.cnki.syfjx.2010.06.060.

WANG Li-sheng, LAI Bao-lin, WU Yang, et al. Effect of Azone on Transdermal Absorption in vitro of Dieda Huoluo Microemulsion Spray[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 26-29. DOI： 10.13422/j.cnki.syfjx.2010.06.060.

摘要

目的:考察不同浓度的渗透促进剂氮酮对跌打活络微乳喷雾剂中蛇床子素和水杨酸甲酯体外透皮吸收的影响。方法:采用Franz扩散池和离体裸鼠皮肤进行体外透皮实验

HPLC同时测定处方中蛇床子素和水杨酸甲酯的渗透量

并计算透皮速率常数、滞后时间。结果:蛇床子素和水杨酸甲酯的体外透皮吸收均符合零级动力学方程;随着氮酮浓度的增加

蛇床子素和水杨酸甲酯的释放速度有降低趋势。结论:本制剂微乳和挥发油本身具有良好的促渗作用

无需另外加入氮酮。

Abstract

Objective:To study the effect of different dosage azone on transdermal absorption in vitro of osthol and methyl salicylate in Dieda Huoluo Microemulsion Spray.Method:The experiment of percutaneous penetration in vitro was operated with the methods of Franz diffusion cell and hairless mice skin

and the penetration quantity of osthol and methyl salicylate was determined by HPLC

and calculate the trandermal rate and lag time.Result:The releasing permeated amount of osthol and methyl salicylate in vitro followed the zero releasing equation.The results showed that the trandermal rate was slower as increased the dosage of azone.Conclusion:The formulation of microemulsion and volatile oil in preparation contributed to the good transdermal absorption in vitro of osthol and methyl salicylate.It’s not necessary to add azone to the preparation.

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Related Author

WANG Li-sheng

LAI Bao-lin

WU Yang

ZHOU Li-ling

LIN Gui-tao1

QI Hong2

SHENG Hua-gang1

LIN Gui-tao

Related Institution

Shandong University of Traditional Chinese Medicine,Ji’nan

Chengde Medical University

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

Hebei New Exciptients Technology Innovation Center of Traditional Chinese Medicine

Jianʹan Pharmaceutical Co. Ltd.

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