ZHOU Yong-ming1, PIAO Bing-kui1, ZHENG Hong-gang1, et al. Investigation on Migration Ability and Mechanism of Dendritic Cells by Feiliuping Extract and its Modified Formula[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 152-155.
ZHOU Yong-ming1, PIAO Bing-kui1, ZHENG Hong-gang1, et al. Investigation on Migration Ability and Mechanism of Dendritic Cells by Feiliuping Extract and its Modified Formula[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 152-155. DOI: 10.13422/j.cnki.syfjx.2010.06.080.
Investigation on Migration Ability and Mechanism of Dendritic Cells by Feiliuping Extract and its Modified Formula
Objective:To observe the migration ability and mechanism of dendritic cells(DC) by Feiliuping extract and its modified formula.Method:The migration ability of DCs were determinated by transwell bordens
the expression of CCR7
CXCR4 on surface of DC were detected by RT-PCR.Result:Different TCM has different influence on migration ability of DCs.And ability was different with different chemotactic factor.The expression of CCR7
CXCR4 on surface of DC were different with different TCM
CCR7 in Yiqi group was the highest
while Huoxue group
FLP group lower
Jiedu group is the lowest.Comparing with Yiqi group
Huoxue group & Jiedu group(P < 0.05).CXCR4 in Yiqi Group & FLP group was highest
Huoxue group is lower
Jiedu group is the lowest.Comparing with blank serum group and FLP group
Yiqi group
Jiedu group(P < 0.01).Conclusion:Yiqi herbs strengthens migration ability of DCs
while Jiedu herbs inhibits.The difference was related to the expression chemotactic factor receptor on DCs surface.
Investigation on Migration Ability and Mechanism of Dendritic Cells by Feiliuping Extract and its Modified Formula
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Related Author
ZHOU Yong-ming
PIAO Bing-kui
ZHENG Hong-gang
XIONG Lu
ZHAO Bao-sheng
HUANG Aoqing
WANG Wenli
LIU Ying
Related Institution
Arura Tibetan Medicine Co.Ltd.
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences
Science and Technology Innovation Center,Guangzhou University of Chinese Medicine
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine
The Second Affiliated Hospital of Guizhou University of TCM