The Influences of Tangbikang on the Oxidative Stress in Rats with Diabetic Peripheral Neuropathy

WANG Jia; LIU Tong-hua

doi:10.13422/j.cnki.syfjx.2010.06.082

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The Influences of Tangbikang on the Oxidative Stress in Rats with Diabetic Peripheral Neuropathy

更新时间：2024-09-23

- The Influences of Tangbikang on the Oxidative Stress in Rats with Diabetic Peripheral Neuropathy
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 6, Pages: 160-163(2010)
- 作者机构：
  
  北京中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.06.082
  CLC： R285.5
- Published：2010
- 稿件说明：
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[1]王佳,刘铜华.糖痹康对糖尿病大鼠血清神经性因子及坐骨神经神经性因子基因表达的影响[J].中国实验方剂学杂志,2010,16(06):160-163.

WANG Jia, LIU Tong-hua. The Influences of Tangbikang on the Oxidative Stress in Rats with Diabetic Peripheral Neuropathy[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 160-163.
[1]王佳,刘铜华.糖痹康对糖尿病大鼠血清神经性因子及坐骨神经神经性因子基因表达的影响[J].中国实验方剂学杂志,2010,16(06):160-163. DOI： 10.13422/j.cnki.syfjx.2010.06.082.

WANG Jia, LIU Tong-hua. The Influences of Tangbikang on the Oxidative Stress in Rats with Diabetic Peripheral Neuropathy[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 160-163. DOI： 10.13422/j.cnki.syfjx.2010.06.082.

摘要

目的:探讨糖痹康对链脲佐菌素（streptozotocin

STZ）诱导的糖尿病周围神经病变（diabetic penipheral neuropathy

DPN）大鼠神经生长因子基因表达的影响。方法:用STZ建立糖尿病大鼠模型

分为正常组、模型组、弥可保组、糖痹康低、中、高剂量组。连续给药8周后处死大鼠

用ELISA法测定血清神经生长因子（NGF）活性

实时荧光定量PCR法检测坐骨神经中NGF基因的表达。结果:与模型组比较

糖痹康中、高剂量组血清NGF水平均显著增高（P<0.01）

坐骨神经NGF基因含量显著增高（P<0.01）。结论:糖痹康能增加糖尿病大鼠NGF蛋白及基因的表达

从而起到对周围神经的保护作用。

Abstract

Objective:To investigate the influences of Tangbikang on the serum nerve growth factor（NGF） concentration and NGF mRNA expression in sciatic nerve in rats with diabetic penipheral neuropathy（DPN）.Method:70 SD rats were randomly divided into two groups:normal control 10 and diabetic penipheral neuropathy 60 by weight.Diabetes was induced by intraperitoneal injection of STZ

55 mg.kg-1.The diabetic models were affirmed upon blood glucose ≥16.7 mmol.L-1.And the diabetic rats were randomly divided into five groups:model group

methycobal treatment group

Tangbikang different dose treatment groups.After drug administration for 8 days

all the rats were sacrificed at week 8;The blood serum was obtained and NGF were detected;The sciatic nerve NGF gene was detected by the Real-time fluorescence quantitative polymerase chain reaction（PCR）.All statistical calculations were made using the SPSS16.0 statistical package.Result:After the treatment by the middle and high dose of Tangbikang

the NGF level（P < 0.01

P < 0.01） in the blood serum increased greatly.The expression of NGF gene incresed（P < 0.01）.Conclusion:Tangbikang can increase the NGF protein and gene expression to play an important role of peripheral nerve protection.

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Related Author

WANG Jia

LIU Tong-hua

LV Cui-yan

LI Qiu-ming

MAO Ying-qiu

LIU Tong-hua

AN Jingwen

SONG Linchun

Related Institution

College of Integrated Traditional Chinese and Western Medicine，Hebei University of Chinese Medicine，Hebei Key Laboratory of Integrated Medicine on Liver-kidney Patterns

International Joint Research Center for Diabetes Prevention and Treatment with TCM， Ministry of Science and Technology

Key Laboratory of TCM Health Sciences， Ministry of Education， Beijing University of Chinese Medicine

College of Traditional Chinese Medicine （TCM）， Beijing University of Chinese Medicine

School of Life Sciences，Beijing University of Chinese Medicine

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