YANG Lei, LI Wei-rong, MI Sui-qing, et al. Inhibitory Effects and Mechanism of Bornel on Arterial Thrombosis Induced by FeCl3 in Rat[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 164-166.
YANG Lei, LI Wei-rong, MI Sui-qing, et al. Inhibitory Effects and Mechanism of Bornel on Arterial Thrombosis Induced by FeCl3 in Rat[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 164-166. DOI: 10.13422/j.cnki.syfjx.2010.06.083.
Inhibitory Effects and Mechanism of Bornel on Arterial Thrombosis Induced by FeCl3 in Rat
Objective:To study on the antithrombotic effect of bornel.Method:Thrombosis test
platelets aggregation
and determination platelet [Ca2 + ]i were carried out to investigate the effects of borneol on the following indexes:weight of thrombus
the concentration of serotonin in platelets
platelet aggregation rate
and intracellular free calcium concentration in platelets.Result:Ig 140 mg.kg-1 borneol daily for 7 days inhibited arterial thrombosis induced by FeCI3
increased the concentration of serotonin in platelets
and inhibited the platelet aggregation induced by 5-HT(P < 0.05);with or without the presence of extracellular Ca2 +
bornel inhibited the increased [Ca2 + ]i induced by 5-HT.Conclusion:Borneol has anti-thrombosis
and its mechanism may be related to inhibitory effects for the release of platelet 5-HT
for platelet aggregation and for the increase of platelet [Ca2 + ]i.
Inhibitory Effects and Mechanism of Bornel on Arterial Thrombosis Induced by FeCl in Rat
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Related Author
YANG Lei
LI Wei-rong
MI Sui-qing
WANG Ning-sheng
YU Meishuang
DAI Guoliang
HANG Huaxi
YE Yu
Related Institution
Affiliated Hospital of Nanjing University of Chinese Medicine
College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM)
Teaching Hospital of Chengdu University of TCM
Henan University of Chinese Medicine
Third Affiliated Hospital of Henan University of Chinese Medicine