The Regulating Effect and its Mechanism of Polysaccharides of Cactus Pear Fruit for Blood Pressure in Spontaneous Hypertension Rat

LIANG Qiu-yun1; LIU Hua-gang1; HUANG Hui-xue2; MENG Hua-lin3; HUANG Yu-mai1

doi:10.13422/j.cnki.syfjx.2010.06.084

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The Regulating Effect and its Mechanism of Polysaccharides of Cactus Pear Fruit for Blood Pressure in Spontaneous Hypertension Rat

更新时间：2024-09-23

- The Regulating Effect and its Mechanism of Polysaccharides of Cactus Pear Fruit for Blood Pressure in Spontaneous Hypertension Rat
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 6, Pages: 167-170(2010)
- 作者机构：
  
  1. 广西医科大学
  2. 广西中医学院
  3. 广西柳州医学高等专科学校
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.06.084
  CLC： R285.5
- Published：2010
- 稿件说明：
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[1]梁秋云,刘华钢,黄慧学,黄育脉,蒙华琳.仙人掌果多糖对自发性高血压大鼠血压的调节及机制[J].中国实验方剂学杂志,2010,16(06):167-170.

LIANG Qiu-yun1, LIU Hua-gang1, HUANG Hui-xue2, et al. The Regulating Effect and its Mechanism of Polysaccharides of Cactus Pear Fruit for Blood Pressure in Spontaneous Hypertension Rat[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 167-170.
[1]梁秋云,刘华钢,黄慧学,黄育脉,蒙华琳.仙人掌果多糖对自发性高血压大鼠血压的调节及机制[J].中国实验方剂学杂志,2010,16(06):167-170. DOI： 10.13422/j.cnki.syfjx.2010.06.084.

LIANG Qiu-yun1, LIU Hua-gang1, HUANG Hui-xue2, et al. The Regulating Effect and its Mechanism of Polysaccharides of Cactus Pear Fruit for Blood Pressure in Spontaneous Hypertension Rat[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 167-170. DOI： 10.13422/j.cnki.syfjx.2010.06.084.

摘要

目的:研究仙人掌果多糖（CPFP）对自发性高血压大鼠（SHR）血压的调节

并探讨其作用机制。方法:15周雄性SHR 50只

随机分为SHR模型组、CPFP高、中、低剂量组和阳性对照组

同龄正常血压的Wistar大鼠10只为正常对照组。各组大鼠首次给药后观察24 h血压变化;连续给药9周

每周测血压1次。9周后

用放射免疫法测定各组大鼠血浆中血管紧张素Ⅰ

Ⅱ（AngⅠ

AngⅡ）及内皮素（ET）

并根据测定AngI的生成速率

计算血浆肾素（RA）活性。结果:给药9周后

CPFP各剂量组使SHR血压明显下降（P<0.05或P<0.01）

降压效果呈现明显的量效和时效关系;CPFP高剂量组的AngII和ET含量较SHR模型组显著降低（P<0.05或P<0.01）。结论:CPFP具有降低SHR血压作用

其机制可能与降低SHR血浆中AngII及ET含量有关。

Abstract

Objective:To investigate the regulating effect and mechanism of the cactus fruit polysaccharides（CPFP） for blood pressure in spontaneous hypertension rat（SHR）.Method:Fifty male SHR at the age of 15 weeks were randomly divided into SHR model group

CPFP high dosage group（H）

CPFP middle dosage group（M）

CPFP low dosage group（L） and captopril treatment group.Another ten male Wistar rats were served as normal control group.The experimental rats were observed for chang in blood pressure during 24 hours after the first administration.The CPFP were administrated for 9 weeks.The systolic blood pressure（SBP） of experimental rats were observed weekly during nine weeks.The contents of angiotensin I

II（AngI

AngII） and endothelin（ET） were determined by radioimmunoassay respectively

and the plasma renin activity（RA） was calculated according to forming speed of AngI after 9 weeks.Result:After 9 weeks

the SBP level in L

M and H group was depressed obviously with the obvious dose-effect and time-effect relation（P < 0.05 or P < 0.01）.The levels of AngII and ET in H group were significantly lower than that in SHR model group（P < 0.05 or P < 0.01）.Conclusion:CPFP can effectively reduce blood pressure in SHR.Reducing the levels of AngII and ET may be account for CPFP effect on SHR.

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Related Author

LIANG Qiu-yun

LIU Hua-gang

HUANG Hui-xue

MENG Hua-lin

HUANG Yu-mai

NIU Chaofeng

ZHANG Peiyu

LI Meng

Related Institution

Dongzhimen Hospital， Beijing University of Chinese Medicine

The First School of Clinical Medicine， Shaanxi University of Chinese Medicine

Affiliated Hospital of Shaanxi University of Chinese Medicine

Second Clinical School of Medicine， Henan University of Chinese Medicine

Henan Province Hospital of Traditional Chinese Medicine

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