XUE Xiao-ping, LI Dong-hua, ZHANG Hao, et al. Experimental Study on the Effect of Qingre Jiedu Fang on the Levels of Endotoxin and Cytokines in Rats with Acute Intra-abdominal Infection[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 176-178.
XUE Xiao-ping, LI Dong-hua, ZHANG Hao, et al. Experimental Study on the Effect of Qingre Jiedu Fang on the Levels of Endotoxin and Cytokines in Rats with Acute Intra-abdominal Infection[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 176-178. DOI: 10.13422/j.cnki.syfjx.2010.06.086.
Experimental Study on the Effect of Qingre Jiedu Fang on the Levels of Endotoxin and Cytokines in Rats with Acute Intra-abdominal Infection
Objective:To explore the effects of Qingre Jiedu Fang(QRJD Fang) on the secretion of endotoxin
TNF-α
IL-6 and IL-10 in intra-abdominal infection rats.Method:After giving 30 min of i.g QRJD Fang or cefi xime(ANT)
rat model of acute bacterial peritonitis was set up.Endotoxin
tumor necrosis factor-α(TNF-α)
interleukin-6(IL-6) and interleukin-10(IL-10) in serum were determined respectively in 6h
12h
18h
24h after acute bacterial peritonitis in the four groups(control group
model
QRJD Fang group
ANT group).Result:Compared with the control group
serum endotoxin
TNF-α
IL-6 and IL-10 in the model were increased obviously(P < 0.01)
while the indexes in QRJD Fang group and ANT group were decreased(P < 0.01 or P < 0.05).Conclusion:QRJD Fang could obviously inhibit the secretion of inflammatory cytokints
such as endotoxin
TNF-α
IL-6 and IL-10 in the acute intra-abdominal infection rats.
Experimental Study on the Effect of Qingre Jiedu Fang on the Levels of Endotoxin and Cytokines in Rats with Acute Intra-abdominal Infection
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Related Author
XUE Xiao-ping
LI Dong-hua
ZHANG Hao
CUI Nai-qiang
SHEN Zhixiang
LU Weimin
SHI Chuan
YE Mengwei
Related Institution
Affiliated Hospital of Nanjing University of Chinese Medicine
The Second Affiliated Hospital of Shandong University of TCM
The First Clinical Medical College,Shandong University of Traditional Chinese Medicine(TCM)
The First Affiliated Hospital of Guangxi University of Chinese Medicine