Effects of Promoting Blood Circulation to Remove Blood Stasis of Puhuang-Wulingzhi Drug Pair in Shaofu Zhuyu Decoction

ZHOU Wei; SU Shu-lan; LIU Pei; HUA Yong-qing; DUAN Jin-ao

doi:10.13422/j.cnki.syfjx.2010.06.087

您当前的位置：

首页 >

文章列表页 >

Effects of Promoting Blood Circulation to Remove Blood Stasis of Puhuang-Wulingzhi Drug Pair in Shaofu Zhuyu Decoction

更新时间：2024-09-23

- Effects of Promoting Blood Circulation to Remove Blood Stasis of Puhuang-Wulingzhi Drug Pair in Shaofu Zhuyu Decoction
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 6, Pages: 179-183(2010)
- 作者机构：
  
  南京中医药大学江苏省方剂研究重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.06.087
  CLC： R285.5
- Published：2010
- 稿件说明：
移动端阅览
[1]周卫,宿树兰,刘培,华永庆,段金廒.蒲黄-五灵脂药对在少腹逐瘀汤活血化瘀效应中的贡献[J].中国实验方剂学杂志,2010,16(06):179-183.

ZHOU Wei, SU Shu-lan, LIU Pei, et al. Effects of Promoting Blood Circulation to Remove Blood Stasis of Puhuang-Wulingzhi Drug Pair in Shaofu Zhuyu Decoction[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 179-183.
[1]周卫,宿树兰,刘培,华永庆,段金廒.蒲黄-五灵脂药对在少腹逐瘀汤活血化瘀效应中的贡献[J].中国实验方剂学杂志,2010,16(06):179-183. DOI： 10.13422/j.cnki.syfjx.2010.06.087.

ZHOU Wei, SU Shu-lan, LIU Pei, et al. Effects of Promoting Blood Circulation to Remove Blood Stasis of Puhuang-Wulingzhi Drug Pair in Shaofu Zhuyu Decoction[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 179-183. DOI： 10.13422/j.cnki.syfjx.2010.06.087.

摘要

目的:评价少腹逐瘀汤、少腹逐瘀汤减蒲黄-五灵脂及蒲黄-五灵脂药对水提物对大鼠急性血瘀模型血液流变性的影响及体外对家兔血小板聚集及凝血酶时间的影响。方法:采用大鼠急性血瘀模型评价少腹逐瘀汤、少腹逐瘀汤减蒲黄-五灵脂及蒲黄-五灵脂药对水提物对血液流变性的影响;采用体外实验观察不同提取物对二磷酸腺苷（ADP）诱导的血小板聚集作用及凝血酶时间（TT）法抗凝血作用的影响。结果:大鼠急性血瘀模型研究结果表明:少腹逐瘀汤能够明显改善急性血瘀SD大鼠全血黏度（P<0.05）、血沉（P<0.05）;且可以延长TT、凝血酶原时间（PT）和部分活化凝血活酶时间（APTT）;而蒲黄-五灵脂药对在降低全血黏度、改善血沉及体外延长家兔血浆凝血时间方面均优于全方减去蒲黄-五灵脂提取物。结论:少腹逐瘀汤对大鼠急性血瘀模型的血液流变性及体外对家兔血小板聚集及凝血酶时间的影响均有显著作用

且蒲黄五灵脂药对对于全方效应起到主要作用

提示蒲黄-五灵脂药对与全方减去蒲黄-五灵脂药味配伍可能存在一定的增效作用

为揭示该药对对全方活血化瘀效应的贡献提供了一定科学数据。

Abstract

Objective:To evaluate the effects of Shaofu Zhuyu decoction

prescription minus Puhuang-Wulingzhi drug pair and Puhuang-Wulingzhi drug pair on hemorheological parameters in rat mode of acute blood stasis

and the influence on platelet aggregation and clotting time in vitro.Method:Rat mode of acute blood stasis was used to evaluate the Changes in hemorheology

the function of blood coagulation and ovarian.The platelet aggregation was tested with Born′s method and thrombin time（TT） method in vitro was established to determine the clotting time.Result:The results stated that Shaofu Zhuyu decoction showed significant improvements in the hemorheological indexes of rats in the model of blood stasis and regulation for the secret function of rat ovarian.Meanwhile

the result of vitro assay showed that Shaofu Zhuyu Decoction had significantly inhibitory effects on the platelet aggregation and prolonged clotting time.The effects of Puhuang-Wulingzhi drug pairare superior to the group of prescription minus Puhuang-Wulingzhi drug pair on reducing whole blood viscosity

plasma viscosity and extending clotting time in vitro.Conclusion: Shaofu Zhuyu decoction can improve the indexes of hemorheology in rat model of blood stasis

and showed significant inhibitory effect on platelet aggregation and clotting time.Furthermore

Puhuang-Wulingzhi drug pair plays the major role in the biological effect for the whole prescription.

关键词

Keywords

references

Views

941

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effects of Promoting Blood Circulation to Remove Blood Stasis of Puhuang-Wulingzhi Drug Pair in Shaofu Zhuyu Decoction

Effects of Promoting Blood Circulation to Remove Blood Stasis of Herbs of Warm Channel and Explling Cold Pair in Shaofu Zhuyu Decoction

Application Regularity and Mechanism of Chinese Marine Drug Pair Haliotidis Concha-Oystreae Concha Based on Literature Mining Technology

Simultaneous Analyze Chemical Components of Inhibiting Mice Uterine Contraction in Active Fraction of Shaofu Zhuyu Decoction

Related Author

DUAN Jin-ao

HUA Yong-qing

LIU Pei

SU Shu-lan

ZHOU Wei

QIAN Da-wei

TANG Yu-ping

DUAN Jin-ao

Related Institution

Jiangsu Key Laboratory for Traditional Chinese Medicine Formulae Reasearch, Nanjing University of Chinese Medicine

Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica

Guangxi Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residuse

Guangxi Key Laboratory of TCM Formulas Theory and Transformation for Damp Diseases

Pharmacy College of Guangxi University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰