Intestine Absorption Study on Danshensu and Salvianolic Acid B with Rat in situ Single Pass Perfusion Model

ZHANG Ying-feng2; LI Yu-jie1; YANG Qing1; WENG Xiao-gang1; DONG Yu3; ZHU Xiao-xin1

doi:10.13422/j.cnki.syfjx.2010.11.035

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Intestine Absorption Study on Danshensu and Salvianolic Acid B with Rat in situ Single Pass Perfusion Model

更新时间：2024-09-23

- Intestine Absorption Study on Danshensu and Salvianolic Acid B with Rat in situ Single Pass Perfusion Model
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 11, Pages: 96-100(2010)
- 作者机构：
  
  1. 广州中医药大学
  2. 中国中医科学院中药研究所
  3. 中国中医科学院广安门医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.11.035
  CLC： R285.5
- Published：2010
- 稿件说明：
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[1]张英丰,李玉洁,杨庆,翁小刚,董宇,朱晓新.大鼠在体单向肠灌流法进行丹参素、丹酚酸B的肠吸收研究[J].中国实验方剂学杂志,2010,16(11):96-100.

ZHANG Ying-feng2, LI Yu-jie1, YANG Qing1, et al. Intestine Absorption Study on Danshensu and Salvianolic Acid B with Rat in situ Single Pass Perfusion Model[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 96-100.
[1]张英丰,李玉洁,杨庆,翁小刚,董宇,朱晓新.大鼠在体单向肠灌流法进行丹参素、丹酚酸B的肠吸收研究[J].中国实验方剂学杂志,2010,16(11):96-100. DOI： 10.13422/j.cnki.syfjx.2010.11.035.

ZHANG Ying-feng2, LI Yu-jie1, YANG Qing1, et al. Intestine Absorption Study on Danshensu and Salvianolic Acid B with Rat in situ Single Pass Perfusion Model[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 96-100. DOI： 10.13422/j.cnki.syfjx.2010.11.035.

摘要

目的:考察丹参水溶性成分-丹参素和丹酚酸B的肠吸收特性。方法:采用大鼠在体单向肠灌流法

测定不同质量浓度丹参素和丹酚酸B在不同肠段、不同浓度的吸收分数（Fa

%）和表观渗透系数（Papp）。结果:丹参素和丹酚酸B在各肠段的吸收均比较差

十二指肠和空肠吸收较回肠和结肠略好

质量浓度、肠段对Fa和Papp无明显影响。结论:丹参素和丹酚酸B在全肠道以被动扩散方式吸收

且吸收比较差

无特定吸收部位

不受药物浓度的影响。

Abstract

Objective:To study the absorption of salvianolic acid B and danshensu.Method:In situ single pass perfusion model was used and the concentration of salvianolic acid B and danshensu in perfusate were determined by HPLC in combination with ultraviolet detector.Result:The apparent penetration coefficient（Papp） and absorption percentage（Fa） of danshensu and salvianolic acid B were all low at different concentration in four different regions of intestine of rat（duodenum

jejunum

ileum

colon）.The absorption rate of dashensu was faster than salvianolic acid B in this study.The values of the Fa a and the Papp were not significantly affected by concentration of perfusion solution and intestinal segments.Conclusion:The intestine absorption characteristics of salvianolic acid B and danhensu was poor at all segments of intestine in rats where there is no special ab sorption site and showed the passive diffusion process.

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Capital Medical University School of Traditional Chinese Medicine

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