GAO Dong1, WU Li-ya1, JIAO Yu-huan1, et al. Effect of VEGF-VEGFR Pathway on EPCs Function Induced by Xuefu Zhuyu Tang[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 104-107.
GAO Dong1, WU Li-ya1, JIAO Yu-huan1, et al. Effect of VEGF-VEGFR Pathway on EPCs Function Induced by Xuefu Zhuyu Tang[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 104-107. DOI: 10.13422/j.cnki.syfjx.2010.11.037.
Effect of VEGF-VEGFR Pathway on EPCs Function Induced by Xuefu Zhuyu Tang
Objective:To observe the effect of VEGF-VEGFR pathway on EPCs function induced by Xuefu Zhuyu Tang.Method:After induced by serial concentrations of Xuefu Zhuyu Decoction-contained serum(XZDCS) and blank serum
EPCs proliferation
migration
adhension ability and VEGF
VEGFR expression were detected by MTT
Boyden chamber
adhension test and RT-PCR respectively.Result:Compared to the control group
10% XZDCS could elevate the cell regeneration and adhension ability.The EPCs migration ability was inhibited by 5% XZDCS and improved by 10%
15% XZDCS.The higher two concentrations could up-regulate VEGF and VEGFR transcription significantly.Conclusion:Xuefu Zhuyu Tang could induce EPCs into angiogenesis by up regulating VEGF-VEGFR pathway to promote its proliferation
Effect of VEGF-VEGFR Pathway on EPCs Function Induced by Xuefu Zhuyu Tang
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Related Author
GAO Dong
WU Li-ya
JIAO Yu-huan
CHEN Wen-yuan
CHEN Yan
LU Bo
SONG Jun
CHEN Ke-ji
Related Institution
School of Nursing, Chengdu University of Traditional Chinese Medicine
The First Clinical School of Henan University of Chinese Medicine
The First Affiliated Hospital of Henan University of Chinese Medicine
Guangdong Provincial Key Laboratory of Research and Development in TCM
Guangdong Provincial Second Hospital of Traditional Chinese Medicine(TCM), Guangdong Provincial Engineering Technology Research Institute of TCM,The Fifth Clinical College of Guangzhou University of Chinese Medicine