Effect of Boschniakia rossica Extracts on Lipid Peroxidation of Lipoproteins in Rabbits with Hyperlipidemia

YIN Xue-zhe1; XU Hui-xian1; JIN Ai-hua2; QUAN Ji-shu2

doi:10.13422/j.cnki.syfjx.2010.11.043

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Effect of Boschniakia rossica Extracts on Lipid Peroxidation of Lipoproteins in Rabbits with Hyperlipidemia

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- Effect of Boschniakia rossica Extracts on Lipid Peroxidation of Lipoproteins in Rabbits with Hyperlipidemia
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 11, Pages: 132-134(2010)
- 作者机构：
  
  1. 延边大学医院
  2. 延边大学基础医学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.11.043
  CLC： R285.5
- Published：2010
- 稿件说明：
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[1]尹学哲,许惠仙,金爱花,全吉淑.草苁蓉提取物对高脂血症家兔血浆脂蛋白脂质过氧化的影响[J].中国实验方剂学杂志,2010,16(11):132-134.

YIN Xue-zhe1, XU Hui-xian1, JIN Ai-hua2, et al. Effect of Boschniakia rossica Extracts on Lipid Peroxidation of Lipoproteins in Rabbits with Hyperlipidemia[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 132-134.
[1]尹学哲,许惠仙,金爱花,全吉淑.草苁蓉提取物对高脂血症家兔血浆脂蛋白脂质过氧化的影响[J].中国实验方剂学杂志,2010,16(11):132-134. DOI： 10.13422/j.cnki.syfjx.2010.11.043.

YIN Xue-zhe1, XU Hui-xian1, JIN Ai-hua2, et al. Effect of Boschniakia rossica Extracts on Lipid Peroxidation of Lipoproteins in Rabbits with Hyperlipidemia[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 132-134. DOI： 10.13422/j.cnki.syfjx.2010.11.043.

摘要

目的:研究草苁蓉提取物（BRE）对实验性高脂血症兔血浆脂蛋白抗脂质过氧化作用的影响。方法:高脂饲料喂养法建立兔高脂血症模型

连续给药8周后分离血浆脂蛋白

观察各血浆脂蛋白过氧化脂质（LPO）含量及低密度脂蛋白（LDL）氧化易感性的变化。结果:饲喂BRE后高脂血症兔血浆总胆固醇（TC）、极低密度脂蛋白胆固醇（VLDL-CH）和低密度脂蛋白胆固醇（LDL-CH）水平明显降低;血浆总LPO和脂蛋白LPO含量明显减少;在体外进行氧化修饰时

LDL氧化延滞时间明显延长。结论:BRE可降低高脂血症兔血脂水平和血浆脂蛋白脂质过氧化程度

增强LDL抗氧化修饰能力

因此能够起到防治动脉粥样硬化症的积极作用。

Abstract

Objective:To study the inhibitory effect of Boschniakia rossica extracts（BRE） on lipid peroxi-dation of plasma lipoproteins in rabbits with hyperlipidemia.Method:The hyperlipidemic model were established by feeding rabbits with high-fat diet.After 8 weeks of treatment

plasma lipoproteins were isolated

and then lipid peroxide（LPO） and susceptibility of low density lipoprotein（LDL） to oxidation was investigated.Result:After the administration with BRE

the levels of plasma total cholesterol（TC）

very low density lipoprotein cholesterol（VLDL-CH） and low density lipoprotein cholesterol（LDL-CH） in hyperlipidemic rabbits were significantly re-duced;LPO levels of plasma and lipoproteins were significantly decreased;and the lag phage of LDL oxidation curve in vitro was noticeably prolonged.Conclusion:BRE

which can reduce blood lipids

decrease the lipid per-oxidizability of lipoproteins and promote resistance to LDL oxidation

may be useful in the prevention and treatment of atherosclerosis.

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Related Author

YIN Xue-zhe

XU Hui-xian

JIN Ai-hua

QUAN Ji-shu

YANG Lele

LUO Danmei

CHEN Jiao

ZHANG Xiaobo

Related Institution

Chengdu University of TCM

Hospital of Chengdu University of Traditional Chinese Medicine （TCM）

Hospital of Chengdu University of TCM

Chengdu University of Traditional Chinese Medicine（TCM）

Research Center for Differentiation and Development of Traditional Chinese Medicine （TCM） Basic Theory/Jiangxi Province Key Laboratory of Biological Etiologies of TCM/First-Level Discipline Platform of Chinese and Western Integrative Medicine/Experimental Animal and Scientific Technology Center of Jiangxi University of Chinese Medicine/School of Pharmacy， Jiangxi University of Chinese Medicine

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