SUN Rong1, WANG Li2, YANG Qian2, et al. Acute Toxicity of Volatile Oil from Bupleurum chinense in Rats and Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 154-156.
SUN Rong1, WANG Li2, YANG Qian2, et al. Acute Toxicity of Volatile Oil from Bupleurum chinense in Rats and Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 154-156. DOI: 10.13422/j.cnki.syfjx.2010.11.049.
Acute Toxicity of Volatile Oil from Bupleurum chinense in Rats and Mice
Objective:To observe the actute toxicity of volatile oil from Bupleurum chinense in mice and rats and evaluate its safety.Method:Ig volatile oil from B.chinense of different dosages to mice and rats;the acute toxi-cal symptoms
signs
death time and accumulated death rate were observed and the LD50 was calculated by Bliss method.Result:Restlessness
abnormal walking
accelerated heart rate
breathlessness
consecutive convulsion were the main acute toxical symptoms and signs caused by volatile oil from B.chinense;the LD50 and its 95% confident limit of volatile oil of B.chinense to rats and mice are 2.081(1.759 9-2.461 3) mL.kg-1 and 3.118(2.872 4-3.391 2)mL.kg-1 differently.Conclusion:Ig volatile oil from B.chinense to rats and mice can cause acute toxi-cal injury to them.The further study on toxical components
toxical cheminisms and toxical targets of volatile oil from B.chinense are need to do
so as to offer experimental basement for the safe and effective application of B.chinense and its preparation.
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Related Author
SUN Rong
WANG Li
YANG Qian
HUANG Wei
LV Li-li
Yu-ping XIA
Chun-hua HE
Zi-shu CHAI
Related Institution
Guangxi Xian Zhu Chinese Medicine Technology Co.Ltd.
Guangxi University of Chinese Medicine
Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine