YUAN Yong1, WANG Lu-mei1, ZHANG Yong-jun1, et al. Optimization of Extraction Process for Fukang Tablets with Orthogonal Design[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(12): 19-22.
YUAN Yong1, WANG Lu-mei1, ZHANG Yong-jun1, et al. Optimization of Extraction Process for Fukang Tablets with Orthogonal Design[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(12): 19-22. DOI: 10.13422/j.cnki.syfjx.2010.12.009.
Optimization of Extraction Process for Fukang Tablets with Orthogonal Design
摘要
目的:优选妇康胶囊的最佳提取工艺。方法:采用正交试验设计
分别以蛇床子素、盐酸小檗碱提取率和浸膏收率为指标
优化黄连、蛇床子等6味药材的提取工艺;以没食子酸提取率和浸膏收率为指标
优选没食子等4味药材的提取工艺。结果:6味药材最佳提取工艺为:10倍量70%乙醇回流提取2次
每次1 h;没食子等4味药材最佳提取工艺为:10倍量水煎煮3次
每次1 h;结论:优选的提取工艺稳定、可行。
Abstract
Objective: To optimize the extraction process of Fukang tablets.Method: Orthogonal design was used to optimize the extracting process of six herb medicines with the extract yield
the content of berberine hydrochloride and osthole as index;to optimize the extracting process of gallic and other two herb medicines with the extract yield and the content of gallic acid as index.Result: The optimum extraction progress was as follows:six herb medicines were extract 2 times for 1 hour with 10 times of 70% alcohol;gallic and other three herb medicines were extract 3 times for 1 hour with 10 times of water.Conclusion: The optimum extraction process was stable and feasible.