LI Dong-hua, BAI Xia, XIE Xiao-lei, et al. Mechanisms for Tongxie Yaofang to Treat Irritable Bowel Syndrome from Point of View of Interaction between Brain and Intestine[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(12): 118-121.
LI Dong-hua, BAI Xia, XIE Xiao-lei, et al. Mechanisms for Tongxie Yaofang to Treat Irritable Bowel Syndrome from Point of View of Interaction between Brain and Intestine[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(12): 118-121. DOI: 10.13422/j.cnki.syfjx.2010.12.013.
Mechanisms for Tongxie Yaofang to Treat Irritable Bowel Syndrome from Point of View of Interaction between Brain and Intestine
Objective: To study the mechanisms of Tongxie Yaofang to treat irritable bowel syndrome from point of view of interaction between brain and intestine.Method: 50 Wister rats were divided randomly into normal group
model group
the large dose of Tongxie Yaofang group
the lower dose of Tongxie Yaofang group and the dicetel group.The rat model of irritable bowel syndrome was made by moving-restriction combined with taking senna decoction
The protein expressions of c-fos were detected by immunohistochemistry in different brain areas and nucleus in brain
the functions of colonic and small intestine were also evaluated by observing the counts of feces
the discharging times of the glass beads and the ink movement in the small intestine in rats.Result: The counts of feces in rats were decreased(P < 0.05)
the discharging times of the glass beads were reduced and the ink movement in the small intestine were markedly decreased(P < 0.01)
the gray values of c-fos protein in different brain areas and nucleus were significantly higher(P < 0.05) in large dose Tongxie Yaofang group in comparison with model group
the protein expressions of c-fos in different brain areas in Tongxie Yaofang group were markedly decreased.Conclusions:Tongxie Yaofang has the effect of regulating the functions of the axis of brain and intestine.
Effect of Tongxie Yaofang with or Without Saposhnikoviae Radix on Water Metabolism and 5-HT Pathway in Irritable Bowel Syndrome Rats
Effect of Tongxie Yaofang on p38 MAPK Pathway Associated Protein and Its Target Gene Expression in Colon Tissues of D-IBS Rats with Liver-stagnation and Spleen-deficiency
Clinical Observation on the Therapeutic Effect of Tongxie Yaofang Combined with Microecological Preparation for Irritable Bowel Syndrome
Multi-target Network Construction and Mechanism Analysis of Main Effective Components of Tongxie Yaofang
Related Author
LI Dong-hua
BAI Xia
XIE Xiao-lei
GENG Jian-guo
ZHANG Wei
GE Wen-jing
WANG Hui-sen
ZHANG Xue-xia
Related Institution
Institute of Chinese Materia Medica, Henan Academy of Traditional Chinese Medicine
Medicine College of Hexi University
Gansu University of Chinese Medicine
Cancer Institute, Chengdu University of TCM
Traditional Chinese Medicine (TCM) Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of TCM