Objective: To observe the protective effect of Zuogui Jiangtang Yishen Recipe（ZGJTYS） on regulating glucose-lipid metabolism and inflammatory cytokines in MKR mice with high-fat diet.Method: Intervention of ZGJTYS was executed in MKR mice with high-fat diet.Fasting blood-glucose（FBG）

insulin（INS）

blood-lipid

hs-CRP and TNF-α levels in serum were examined.Result: Compared with MKR mice

FBG level in the mice with high-fat diet elevated（but P > 0.05）;INS

total cholesterol（TCHO）

high density lipoprotein cholesterol（HDL-C）

low-density lipoprotein cholesterol（LDL-C）

LDL-C /HDL-C

hs-CRP and TNF-α in the mice with high-fat diet were higher than those in control MKR mice.（P < 0.05 or P < 0.01）

but TG level reduced（P < 0.01）.After intervention of ZGJTYS

FBG

INS

TG

TCHO

LDL-C

LDL-C /HDL-C

hs-CRP

TNF-α in the mice with high-fat diet decreased significantly（P < 0.05 or P < 0.01）

while HDL-C level significantly increased（P < 0.05）.Conclusion: ZGJTYS could significantly improve insulin resistance

regulate glucose-lipid metabolism

and reduce inflammatory cytokines.