Does-effect Relationship and Time-effect Relationship of Sinisan Powder Improving Sleeping of Drosophila melanogaster

LI Yu-ping; XU Rui-xin; LI Ting-li

doi:10.13422/j.cnki.syfjx.2010.12.033

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Does-effect Relationship and Time-effect Relationship of Sinisan Powder Improving Sleeping of Drosophila melanogaster

更新时间：2024-09-23

- Does-effect Relationship and Time-effect Relationship of Sinisan Powder Improving Sleeping of Drosophila melanogaster
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 12, Pages: 109-111(2010)
- 作者机构：
  
  黑龙江中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.12.033
  CLC： R285.5
- Published：2010
- 稿件说明：
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[1]李玉萍,徐瑞鑫,李廷利.四逆散冻干粉改善果蝇睡眠作用的量效时效关系研究[J].中国实验方剂学杂志,2010,16(12):109-111.

LI Yu-ping, XU Rui-xin, LI Ting-li. Does-effect Relationship and Time-effect Relationship of Sinisan Powder Improving Sleeping of Drosophila melanogaster[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(12): 109-111.
[1]李玉萍,徐瑞鑫,李廷利.四逆散冻干粉改善果蝇睡眠作用的量效时效关系研究[J].中国实验方剂学杂志,2010,16(12):109-111. DOI： 10.13422/j.cnki.syfjx.2010.12.033.

LI Yu-ping, XU Rui-xin, LI Ting-li. Does-effect Relationship and Time-effect Relationship of Sinisan Powder Improving Sleeping of Drosophila melanogaster[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(12): 109-111. DOI： 10.13422/j.cnki.syfjx.2010.12.033.

摘要

目的:研究四逆散冻干粉改善果蝇睡眠作用的量-效与时-效关系。方法:选取野生型Canton S品系黑腹果蝇为试验对象

利用自动红外果蝇活动监测系统

以果蝇24 h总睡眠时间为观察指标

分别进行四逆散冻干粉改善睡眠作用的量-效与时-效关系的研究。结果:雌雄果蝇的24 h总睡眠时间随着给药剂量的增加而增加

具有一定的剂量依赖关系

雌果蝇的最大有效剂量是4%

而雄果蝇的最大有效剂量为2%

雌果蝇连续给药4 d果蝇24 h总睡眠时间最长

而雄果蝇连续给药7 d

其24 h总睡眠时间最长。结论:四逆散冻干粉能促进果蝇的睡眠

但对雌、雄果蝇睡眠的影响程度不同。雌果蝇给药高浓度短时间效果较好

雄果蝇给药低浓度长时间效果好。

Abstract

Objective: This paper aims to identify the relation of the dose-effect and time-effect of freezingdried powder of Sinisan for sleep improvement.Method: We selected the 7-day-old wild-type Canton S Drosophila melanogaster

and used an Infrared Drosophila Activity Monitor System（DAMS;Trikinetics Inc.USA） to record sleep state of them.We observed and analyzed the recording data for continuous 24 hr.Then we studied the doseeffect and time-effect of Freezing dried powder of Sinisan in Drosophila sleep improvement.Result: 24 hour total sleep time of Drosophila increased as dose increased

it had a definite dose-effect.4% drug substratum for dose

4 days for delivery time is best for female

and 2% drug substratum for dose

7 days for delivery time is best for male.Conclusion: Freezing dried powder of Sinisan can promote the Drosophila sleep

but there are different influence degree in male and female Drosophila.Administration of high concentrations and short-term is best fo female

and low concentrations and long-term is best for male.

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Related Author

LI Yu-ping

XU Rui-xin

LI Ting-li

LI Jiaxin

YAN Yupeng

LI Gaifen

JIA Haihua

LI Zhigeng

Related Institution

Institute of Basic Theory of Traditional Chinese Medicine， China Academy of Chinese Medical Sciences

The First Affiliated Hospital of Harbin Medical University

School of Chinese Materia Medica， Beijing University of Chinese Medicine

Reproductive and Genetic Medical Center， Dalian Women and Children's Medical Group

Pharmaceutical Factory of Beijing Tongrentang Technology Development Co. Ltd.

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