SHI Zhi-qi1, DU Jian-ping1, DU Tie-liang2. Experimental Study on Therapeutic Effect of Centella Total Glucosides on Acetic Acid-induced Gastric Ulcer in Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(12): 122-124.
SHI Zhi-qi1, DU Jian-ping1, DU Tie-liang2. Experimental Study on Therapeutic Effect of Centella Total Glucosides on Acetic Acid-induced Gastric Ulcer in Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(12): 122-124. DOI: 10.13422/j.cnki.syfjx.2010.12.036.
Experimental Study on Therapeutic Effect of Centella Total Glucosides on Acetic Acid-induced Gastric Ulcer in Rats
Objective: To explore the therapeutic effect of Centella total glucosides on acetic acid-induced gastric ulcer in rats.Method: Rats were divided into control group
ulcer control group
Hedgehog Fungus extract group
Rabeprazole Sodium
and Centella total glucosides(1.62
0.81
0.405 g·kg-1) groups at random
10 rats in each group.After administered for 2 weeks consecutively
all the rats were sacrificed.The area of ulcer and pathological section in gastric mucosa were measured and observed.Result: Compared with ulcer control group and Hedgehog Fungus extract group
in Centella total glucosides(1.62
0.81 g.kg-1) groups
the area of ulcer was decreased significantly(P < 0.05).But compared with Rabeprazole Sodium groups
there was no significance.The level of IgM(P < 0.05)
IgG(P < 0.05)
IgA(P < 0.01) and IL-2(P < 0.01) were also significantly promoted in Centella total glucosides(1.62 g.kg-1) groups.Conclusion: Centella total glucosides(1.62
0.81 g·kg-1) has good therapeutic effect on acetic acid-induced gastric ulcer in rats
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Related Author
SHI Zhi-qi
DU Jian-ping
DU Tie-liang
LI Jiaze
SHEN Xiaopu
XIANG Xi
GUO Hui
GONG Man
Related Institution
The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine
School of Pharmacy, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine
School of Pharmacy of Anhui University of Chinese Medicine,Anhui Province Key Laboratory of Chinese Medicinal Compounds,Synergetic Innovation Center of Anhui Authentic Chinese Medicine, Heifei
Academy of Traditional Chinese Medicine,Henan University of Chinese Medicine
Li Zhenhua Institute of Academic Thought, Henan University of Chinese Medicine