LIU Bin, MA Yuan-yuan, MAO Wen-jing, et al. Influence of Shenxiong Huayu Capsule on Ultra-microstructure of Hippocampal CA1Area in Vascular Dementia Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(12): 125-128.
LIU Bin, MA Yuan-yuan, MAO Wen-jing, et al. Influence of Shenxiong Huayu Capsule on Ultra-microstructure of Hippocampal CA1Area in Vascular Dementia Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(12): 125-128. DOI: 10.13422/j.cnki.syfjx.2010.12.037.
Influence of Shenxiong Huayu Capsule on Ultra-microstructure of Hippocampal CA1Area in Vascular Dementia Rats
Objective: To study the influence of Shenxiong Huayu Capsule on ultrastructures of hippocampal CA1 area in rats with vascular dementia(VD).Method: The vascular dementia model of rat was established by clamping and releasing the common carotid arteries of both sides repeatly and intraperitoneal injection of sodium nitroprusside(SNP).The SD rats were evenly randomized into 4 groups: sham-operation group
VD model group
Hydergine group and Shenxiong Huayu Capsule intervention group.Cognitive ability of rats was studied with the Morris water maze.The changes in ultra-microstructure of neural cells were observed by transmission electron microscope.Result: VD model demonstrated decrease in cognitive ability(P < 0.01)
Shenxiong Huayu Capsule and Hydergine group alleviated cognitive ability significantly(P < 0.01).In the model group
most of the neurons in CA1 region showed pyknosis
chromatin agglutination
heterochromatin margination
mitochondria swelling.In the Hydergine group
the neurons showed small amounts chromatin agglutination and mitochondria swelling.In the Shenxiong Huayu Capsule group
the distribution of chromatin was well-proportioned
and normal mitochondrion and other organelle were observed.Conclusion Shenxiong Huayu Capsule may protect neural cell through improving ultra-microstructure of hippocampal CA1 area in VD Rats.Shenxiong Huayu Capsuleimproves cognitive ability in VD rats.
Protective Effect and Mechanism of Extracts from Ginseng Radix et Rhizoma,Anemarrhenae Rhizoma and Paeoniae Radix Rubra on Hippocampal Neurons in Rats with Vascular Dementia
Effect of Shenxiong Huayu Capsule on Expression of p38MAPK in CA1 Area of Hippocampus in Vascular Dementia Rats
Effects of Shenxiong Huayu Capsule on Apoptosis and Expression of Bcl-2 and Bax Protein in CA Area of Hippocampus in Vascular Dementia Rats
Shenxiong Huayu Capsule Improves Learning and Memory Behaviors in Rats with Vascular Dementia
Related Author
LIU Bin
MA Yuan-yuan
MAO Wen-jing
LI Jian-min
ZHANG Ai-guo
ZHANG Jin-xia
Yang-yang GUO
Zhen-yun HAN
Related Institution
Dongfang Hospital, Beijing University of Chinese Medicine
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine
Heilongjiang University of Chinese Medicine
Graduate School of Heilongjiang University of Chinese Medicine